Cardioprotective Effect of Scleria lithosperma on Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats
C. P. Karunasree, P. Prasad, V. Jayashankar Reddy, M. Madakka
Annual Research & Review in Biology · pp. 1–9 · Published 6 Nov 2015
10.9734/ARRB/2015/11369Abstract
Aim: The present study was designed to evaluate the protective effects of ethanolic extract of whole plant of Scleria lithosperma (EEWSL) against doxorubicin-induced cardiotoxicity in rats. Methodology: EEWSL was orally administrated in two different doses (250 mg/kg/day and 500 mg/kg/day) to wistar albino rats for 28 days and then intoxicated with doxorubicin (20 mg/kg) by intraperitoneal injection to induce myocardial toxicity. Lipid profile (Total cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein-cholesterol (LDL-C) and High Density Lipoprotein-cholesterol (HDL-C)), antioxidant marker enzymes (Cardiac superoxide dismutase, Cardiac catalase activity, Glutathione reductase activity) and liver diagnostic marker enzymes (SALT, SAST, Creatine phosphokinase, Lactate dehydrogenase) were measured at the end of experimental period. Histopathological changes of heart were observed with optical microscopy. Results: Doxorubicin (DOX) alone injected rats showed altered lipid profile and significant increase in serum markers (Serum glutamate pyruvate transaminase, Serum glutamate oxaloacetate tranaminase, Lactate dehydrogenase and Creatine phosphokinase) of heart injury and lipid peroxidation. Levels of endogenous antioxidant enzymes were also decreased when compared to normal control group. EEWSL pretreatment of DOX-challenged rats significantly reduced the risk of cardiotoxicity by decreasing the levels of liver diagnostic marker enzymes, TC, TG, LDL-C and VLDL-C and increasing the levels of HDL-C and antioxidant enzymes (cardiac superoxide dismutase, Cardiac catalase activity, Glutathione reductase activity) Histopathology of DOX- induced heart of rats pretreated with EEWSL showed a significant recovery from necrosis. Conclusion: Current findings suggest that EEWSL has protective effects against DOX induced cardiotoxicity and this can be attributed due to its antioxidant properties and inhibition of lipid peroxidation.
References (26)
- 1 A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES [DOI]
- 2 A simple method for clinical assay of superoxide dismutase. [DOI]
- 3 A simple fluorometric assay for lipoperoxide in blood plasma [DOI]
- 4 Indian Medicinal Plants: An Illustrated Dictionary [DOI]
- 5 Practical Pharmacognosy [DOI]
- 6 Role of Oxidative Stress in Cardiac Hypertrophy and Remodeling [DOI]
- 7 Doxorubicin cardiotoxicity: analysis of prevailing hypotheses [DOI]
- 8 A Text-Book of Pharmacognosy [DOI]
- 9 Purification and properties of glutathione reductase of human erythrocytes [DOI]
- 10 A Text Book Of Pharmacognosy
- 11 Adriamycin cardiomyopathy: pathophysiology and prevention [DOI]
- 12 Adriamycin-induced Cardiomyocyte and Endothelial Cell Apoptosis: In Vitro and In Vivo Studies [DOI]
- 13 Effect of Green Tea and Vitamin E Combination in Isoproterenol Induced Myocardial Infarction in Rats [DOI]
- 14 Protective effects of Terminalia arjuna against Doxorubicin-induced cardiotoxicity [DOI]
- 15 Intracellular distribution of peroxynitrite during doxorubicin cardiomyopathy: evidence for selective impairment of myofibrillar creatine kinase [DOI]
- 16 Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation [DOI]
- 17 Early changes in myocardial antioxidant enzymes in rats treated with adriamycin [DOI]
- 18 Metallothionein protects against doxorubicin-induced cardiomyopathy through inhibition of superoxide generation and related nitrosative impairment [DOI]
- 19 Ethnomedicinal plants used by Kanikkars of Agasthiarmalai Biosphere Reserve, Western Ghats
- 20 Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment [DOI]
- 21 Diagnostic value of serum creatine kinase and lactate dehydrogenase isoenzyme determinations for monitoring early cardiac damage in rats [DOI]
- 22 Cardioprotective effect of aqueous, ethanol and aqueous ethanol extract of Aerva lanata (Linn.) against doxorubicin induced cardiomyopathy in rats [DOI]
- 23 Cardioprotective effect of Spathodea campanulata bark on isoproterenol-induced myocardial infarction in rats [DOI]
- 24 Early changes in myocardial antioxidant enzymes in rats treated with adriamycin [DOI]
- 25 Adriamycin stimulates low-affinity Ca2+ binding and lipid peroxidation but depresses myocardial function [DOI]
- 26 Free radicals in biology and medicine [DOI]
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