Cardio Protective Role of Novel Gemmo Therapeutically Treated Glycyrrhizaglabra against Isoproterenol Induced Myocardial Injury

Abstract

Aim: To explore cardio protective potential of Glycyrrhiza glabraas against chemically induced myocardial injury in experimental animals by using their blood (serum) for subsequent determination of enzyme levels. Methodology: Glycyrrhizaglabra with known cardio protective potential was used against chemically induced myocardial injury in experimental animals. These animals were divided into seven groups having ten animals each. Seventy rabbits of both sexes, 1-1.5 kg weight was included while pregnant rabbits weight >1.5 kg were excluded. Glycyrrhiza glabraleaves after gemmo-therapeutic treatment were subjected for phytochemical screening. The blood was drawn from the neck region; serum was separated for biochemical analysis. Pretreatment with native and gemmo-extract resisted to rise (P≤0.05) cardiac enzymes (CK-MB, SGOT, sGPT, LDH). Results: Phytochemical screening for alkaloids 7% & 7.5%, flavonoids 21% & 24%, glycosides 16% and 20%, tannic acid10% & 15.5%, and saponins 8% & 15% in gemmo and native extract respectively. Conclusion: It was studied that in isoproterenol injured rabbits, gemmo-extract was significantly better (P≤0.05) than native-extract in curative as well as in preventive treatment to normalizing serum cardiac enzymes.