Cardiac Protection Activity of Ethanol Extract of White Curcumin (Curcuma Zedoaria), Against Cyclophosphamid Induced Cardiovascular Complications in Male Rat

Abstract

Objective: The common side effects associated with cyclophosphamide administration are bone marrow suppression, exposure to infections, as well as cardiovascular complications, including sinus bradycardia, pericarditis, myocarditis, and type 1 heart problems. The present study was sought to investigate the effect of curcumin on modulating side effectt of cyclophosphamide and the mechanisms involved.  Methods: This experimental study was carried out in the Department of Pharmacology, North Sumatra University during 2020.  Thirty Wistar albino male rats, weighing 100 to 150 g (initial body weight); aged 85 to 100 days were selected for the study. After acclimatization for 14 days.  Rats (n = 30) were pretreated with catechin (200 mg/kg, p.o.) alone, normal sample and different dose combination of curcumin (200, 400, 800 mg/kg, p.o.) in 10th day. The whole rats in each groups fed on 150 mg/KgBW of cyclophosphamide solution on days 11th to 15th of the trial The heart was remove blood was taken Serum creatine kinase-MB (CK-MB) level was estimated by IFCC method and Troponin T (cTnI) level by ELISA method. The blood samples were collected and complete blood count were measured by cell counter. The statistical analysis was done by one way ANOVA followed by Tukey post hoc test, with coefficient interval of 95% (α = 0,05). Results: The results revealed that the CKMB and Troponin T levels decreased along with a dosage increase in thegroup with ethanol extract of white turmeric and an improvement in homeostasis and the histopathology of the liver of the rats. The  impact of white turmeric is protective against cardiac cell damage of mice.