Plasma Exchanges: Observational Study at the Mohammed V Rabat Military Training Hospital Blood Transfusion Center from January 2016 to December 2019

Abstract

Since their initial indications as the ultimate treatment for certain serious pathologies, plasma exchanges (PE) have been utilized as frontline therapies up to lifesaving interventions. In this observational study conducted at the Mohammed V Military Training Hospital Blood Transfusion Center from January 2016 to December 2019, we aimed to elucidate the practical modalities and therapeutic indications of plasma exchanges. Our findings revealed that among the patients treated, the majority suffered from neurological pathologies (37%), followed by autoimmune pathologies such as thrombotic thrombocytopenic purpura and thrombotic microangiopathy (25%), and finally haematological and nephrological pathologies, each representing 19%. These results align with existing literature, emphasizing the prevalence of neurological indications for plasma exchanges. Moreover, the study showcased the effectiveness of plasma exchanges in various neurological conditions, with notable sessions for myasthenia, multiple sclerosis, neuromyelitis, polyradiculoneuritis, and meningoencephalitis. For nephrological pathologies, the sessions were primarily conducted for patients with ANCA+ intra-alveolar haemorrhage and Wegener's disease. Additionally, plasma exchanges demonstrated significant clinical improvements in patients with haematological pathologies, such as Waldenstrom's disease and hemolytic anaemia, and autoimmune diseases like thrombotic thrombocytopenic purpura and thrombotic microangiopathy. Ultimately, this study underscores the importance of collaboration between the transfusion centre and clinical and biological services for optimal patient management. The insights gained contribute to the broader understanding of plasma exchange applications in various pathologies, emphasizing its role as a crucial therapeutic intervention.