Blood association of Dopamine and Serotonin with Biochemical and Oxidative Stress Markers in Epilepsy Patients

Abstract

In general, epilepsy common neurological disorder affecting central nervous system, so it represents a significant public health and social burden. The primary cause of epileptic seizures is the excessive discharge of abnormal electrical charges from nerve cells. Epilepsy affects people in general, but is more common in elderly patients. The study included (35) patients with epilepsy (25) males and (10) females. Also, (35) control group (healthy) including (20) males and (15) females. The blood was taken by drawing blood from the vein after sterilizing the drawing area, using a 5 ml needle (syringe) of the type that is thrown away immediately after use (disposable syringe). The blood is then placed in tubes containing a gelatinous substance, in order to separate the clotted part from the serum when placed in a centrifuge at a speed of (3500) for (10) minutes, then the serum is withdrawn, placed in dry plastic tubes and stored at temperatures of 4 until it is used in the bio-endurance scale specified in the research, which included: Dopamine, serotonin, uric acid, creatinine, vitamin C, vitamin E, glutathione, peroxynitrite. In conclusion epilepsy patients showed clear raise in neurotransmitter, biochemical indicators, vitamin C, and peroxynitrite levels. In contrast, significant reductions in vitamin E and GSH levels in epilepsy patients compared to the control group.