Hepatoprotective and Hematological Effects of Solanum melongena (Garden Egg), Solannum lycopersicum (Tomato) and Daucus carrots Subsp. Sativus (Carrot) Extracts against Lead Induced Toxicity in Wistar Rats

Abstract

Background of the Study: Lead effects were assessed by analyzing the impacts of the extract on the liver enzyme concentrations and hematology parameters. Materials and Methods: Thirty five male wistar rats weighing 85-110 g were distributed into five groups consisting of seven rats each. Group I served as control group, group II served as the test group, groups III, IV and V served as treatment groups. Lead acetate solution was given to the rats orally at a dose of 50 mg/kg body weight and 200 mg/kg of fruit extracts for 14 days. On day 15, biochemical analysis were carried out. Results: Effects of extracts showed that ALT,AST and ALP concentration in group II was observed to be significantly (p<0.05) higher than the control and treatment groups with values. The hematology results showed that lead did not cause a significant reduction in the packed cell volume, white blood cell and red blood cell counts. However, the group treated with carrot and garden egg showed slight increase in RBC and WBC count when compared with the positive and negative control groups. Conclusion: From the results above, it showed that the fruits extract have hematopoietic potentials and hence aid in the hepatoprotection of the liver of lead induced Wistar rats.