Protection Effect of Different Fractions of Root of Lawsonia inermis on 2-Deoxyribose by Hydroxyl (.OH) Radical Assay
Mina Basirian, V. Ch. Jeevani, S. N. Manjula, K. Mruthunjaya
Journal of Advances in Medicine and Medical Research · pp. 1–7 · Published 22 Aug 2016
10.9734/BJMMR/2016/27856Abstract
Aim: In vitro protective effect of different fractions of root of Lawsonia inermis (LI) on 2-deoxy ribose, sugar of the DNA were carried out in this study. Methods: Protective activity of different fractions of LI namely ethyle acetate (LIEAC), alcoholic (LIALC), petroleum ether (LIPET), buthanol (LIBUT) and aqueous (LIAQ) with different concentration were evaluated on 2-Deoxyribose (sugar moiety of the DNA) against hydroxyl radical as clastogen. Results: Protection of deoxyribose of DNA against hydroxyl radical induced damage was observed in all the fractions of LI, but LIEAC showed more protective activity. Conclusion: Protective activity of different fractions was due to anti-oxidant property which is directly related to total phenolic and flavonoid content but still further investigation required to claim the protective activity of these fractions.
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