Synthesis, Biological Activity and Applications of 1,2,5-Oxadiazol:  A Brief Review

João Rufino de Freitas Filho; Jucleiton José Rufino de Freitas; Juliano Carlo Rufino de Freitas; Clécio de Souza Ramos; Fabrícia Aparecida Marques de Souza; Jaqueline Ferreira Ramos; Ricarte Tavares; Drielly Emanoele Tomé Barros de Oliveira

doi:10.9734/irjpac/2023/v24i1798

Research Article Open access CC BY 4.0

Synthesis, Biological Activity and Applications of 1,2,5-Oxadiazol: A Brief Review

João Rufino de Freitas Filho, Jucleiton José Rufino de Freitas, Juliano Carlo Rufino de Freitas, Clécio de Souza Ramos, Fabrícia Aparecida Marques de Souza, Jaqueline Ferreira Ramos, Ricarte Tavares, Drielly Emanoele Tomé Barros de Oliveira

International Research Journal of Pure and Applied Chemistry · pp. 1–26 · Published 5 Jan 2023

10.9734/irjpac/2023/v24i1798

Abstract

Oxadiazoles are heterocyclic compounds that belong azole class which contain two nitrogen atoms and one oxygen, forming a five-membered heterocyclic ring. Four isomers of oxadiazoles are described in the literature. Among these, 1,2,4-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole have several applications biological. Compounds of this type have been used in the treatment of various diseases in both humans and animals.Among the immense class of heterocycle compounds with important biological activities already identified, the 1,2,5-oxadiazoles have stood out for the wide variety of applications in medicinal chemistry, in material, and agricultural chemistry. In this work, the main synthesis methods and advances for obtaining 1,2,5-oxadiazoles and their derivatives reported in the literature over the years are reviewed, as well as the applications of these compounds in several branches of chemistry and their biological activities discovered until the moment. GRAPHICAL ABSTRACT:

1,2,5-oxadiazoles biological activities medicinal chemistry NO donor

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João Rufino de Freitas Filho, Jucleiton José Rufino de Freitas, Juliano Carlo Rufino de Freitas, Clécio de Souza Ramos, Fabrícia Aparecida Marques de Souza, Jaqueline Ferreira Ramos, Ricarte Tavares, Drielly Emanoele Tomé Barros de Oliveira (2023). Synthesis, Biological Activity and Applications of 1,2,5-Oxadiazol: A Brief Review. International Research Journal of Pure and Applied Chemistry , 1–26. https://doi.org/10.9734/irjpac/2023/v24i1798

Affiliations

João Rufino de Freitas Filho — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Jucleiton José Rufino de Freitas — Universidade Federal Rural de Pernambuco, Cabo de Santo Agostinho, 54518-430, Pernambuco, Brazil.
Juliano Carlo Rufino de Freitas — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil and Centro de Educação e Saúde, Universidade Federal de Campina Grande, Olho D’agua da Bica, s/n, Cuité, 58175-000 PB, Brazil.
Clécio de Souza Ramos — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Fabrícia Aparecida Marques de Souza — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Jaqueline Ferreira Ramos — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Ricarte Tavares — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.
Drielly Emanoele Tomé Barros de Oliveira — Programa de Pós-Graduação em Química, Universidade Federal Rural de Pernambuco, Dois Irmão, Recife, 52171-900, Pernambuco, Brazil.

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