Evaluation of the Levels of Some Haemostatic Parameters in Women with Uterine Fibroid in Port Harcourt, Nigeria

Abstract

Uterine fibroid is a common gynaecological condition that affects the health of women globally. This cross-sectional study evaluated the levels of some haemostatic parameters in women with uterine fibroid. The study involved 240 subjects who were within the ages of 20 and 45 years. These include 120 women with uterine fibroid and another 120 who were the control subjects. The subjects were selected using simple random sampling technique. Blood samples (5 ml) were collected from each subject into plain bottles for the analyses of von willebrand factor, transforming growth factor beta, fibrinogen and collagen using ELISA technique. The data generated were analyzed using statistical software for social sciences (SPSS) software version 27, and results expressed as mean ± standard deviation. The results showed that the mean levels of von willebrand factor in the uterine fibroid subjects (37 .64 ± 5.94 ng/ml) was significantly higher than the mean levels in the control subjects (24.54 ± 4.43 ng/ml). Also, the mean levels transforming growth factor (6.24 ± 0.96 ng/ml), collagen (795.49 ± 119.02 ng/ml) and fibrinogen (13.7 ± 1.69 mg/ml) were significantly than the mean levels of transforming growth factor (3.32 ± 0.88 ng/ml), collagen (583.60 ± 97.86 ng/ml) and fibrinogen (11.43 ± 1.26 mg/ml) in the control subjects. There were no significant differences in the parameters among the subjects with uterine subjects based on age brackets. The study has shown that there are significant alterations in the levels of these parameters in women with uterine fibroids. It is important that these alterations be considered in the management of the condition in affected women.