Association of MMP 9-1562 C/T Single Nucleotide Polymorphism with the Susceptibility to Lung Cancer Disease in South Iranian Population

Abstract

Aims: The aim of this study was to investigate the association of MMP9 -1562 C /T single nucleotide polymorphism with lung cancer in south Iranian population. Matrix metalloproteinases (MMPs) are a family of highly conserved metal-dependent proteolytic enzymes that are able to degrade ECM components and regulate various cell behaviors. Among several candidate genes, MMP9 is one of the most important genes known to play a key role in relation to lung cancer initiation and progression. A common -1562(C/T) single nucleotide polymorphism in the promoter region of MMP9 was reported to have an association with lung cancer disease. Study Design: A case - control study was carried out using 90 lung cancer patients and 100 healthy controls. Place and Duration of Study: Cellular and Molecular Gerash Research Center, Shiraz University of Medical sciences, shiraz, Iran, between 2010-2012. Methodology: The association of MMP9 promoter single nucleotide polymorphism and lung cancer was examined in a PCR-RFLP method. Our results suggest an association between MMP9 single nucleotide polymorphism and lung cancer initiation and progression. Conclusion: According to our results, the frequency of T allele in patient group (OR=4.6111, 95% CI, 1.9005 to 11.1879) and TT genotype in smoker group (OR=1.7726, 95% CI, 0.7947 to 3.9538) is higher compared to other groups.