Association of Hematological Parameters with Nottingham Histologic Grades of Breast Carcinoma in South Indian Population

Abstract

Aim: To determine the most reliable hematological markers for the prognosis of breast cancer. To evaluate the correlation between hematological parameters and histopathological grading. Study Design: A retrospective study Place of Study: This study was carried out in Saveetha Medical College and Hospital, Tamil Nadu, India. Methodology: Study was started after obtaining the approval from the ethics committee. Histopathological grades 1, 2 and 3 of breast cancer patients were correlated with their hematological parameters. Results: Out of 104 cases of breast carcinoma, maximum of cases were seen in histopathological grade 2, followed by grade 3 and grade 1 respectively. On correlation with hematological parameters, Hb concentration, RBC count, PCV , MCV , TLC , DLC(neutrophil, lymphocytes) and Absolute lymphocyte count was decreased as the grade increase. RDW increased with higher the grade. Neutrophil lymphocytes ratio showed statistically increased increase in histopathological grade 3 when compared to grade 1. Conclusion: Our study showed that the hematological parameters like hemoglobin, RBC count, PCV, WBC count, platelet count, absolute neutrophil count, absolute lymphocyte count, NLR in breast cancer can be a useful guide for disease progression.