Association between Interleukin 6 Gene Polymorphism and Human Papilloma Virus Infection in Oral Squamous Cell Carcinoma Patients
Mehwish Zafar, Naila Irum Hadi, Saeeda Baig, Nosheen Zehra
Journal of Advances in Medicine and Medical Research · pp. 1–9 · Published 23 Aug 2015
10.9734/BJMMR/2015/20044Abstract
Aims: To find out an association between Human Papilloma Virus and IL 6 gene polymorphism in Oral Squamous Cell Carcinoma patients. Study Design: Cross-sectional study. Place and Duration of Study: Ziauddin Hospital (Dental OPD), Karachi, Pakistan. In between the period of January 2014 to May 2015. Methodology: This cross-sectional study consisted of a total of 140 oral squamous cell carcinoma patients of 18 years and above (104 males and 36 females). Detailed questionnaire followed by sample collection from each patient was done. These samples were analyzed by polymerase chain reaction for human papilloma virus and IL 6 gene polymorphism was analyzed through restriction fragment length polymorphism. Results: Mean age of the patients was 43.5±11.84 years (range 31-40 years). Most of the patients (45; 32.1%) belonged to the Urdu speaking ethnic group. Pan (87; 62.1%) and Gutka (82; 58.6%) were used by most of the patients. (17;12.1%) patients had history of systemic disease (e.g hypertension, diabetes). And (3021.4%) patients had a positive family history of OSCC. The most common site of OSCC was buccal mucosa (86; 61.4%) in these patients. Majority of the patients (77; 55%) had histologically moderately differentiated OSCC, and more than half of these patients (78; 55.7%) had Group B (stage III & IV) of OSCC. (12;8.6%) out of 140 samples tested positive for human papilloma virus gene and the following pattern was observed for IL 6 gene polymorphism, GG: (46.4%), GC (39.3%), CC (14.3%). A positive association was observed for Group B (stages III & IV) of oral squamous cell carcinoma with IL 6 genotypes: GC heterozygote (OR=3.819, 95% CI=1.782-8.183, P=0.001) and CC homozygote (OR=6.833, 95% CI=2.046-22.822, P=0.002), and also a strong positive association was found between human papilloma virus and CC homozygote genotype (OR=21.333, 95% CI=2.318-196.311, P=0.007). Conclusion: Human papilloma virus association with IL 6 gene polymorphism in oral squamous cell carcinoma patients suggests rapid and aggressive progress of oral carcinogenesis.
Cited by 1
Zil-e-Rubab, Saeeda Baig, Uzma Zaman · International Journal of Infectious Diseases · 2018
Related research
- Determination of CA 125 Salivary Level with Clinicopathological Characteristics in Oral Squamous Cell Carcinoma in Karachi — shares topic coverage
- Oral Candidiasis: Complication of Concomitant Chemo-radiotherapy in Patients with Oral Squamous Cell Carcinoma — shares topic coverage
- Evaluation of Infiltration of Immunological cells (Tumour Associated Tissue Eosinophils and Mast cells) in Oral Squamous Cell Carcinoma by Using Special Stains — shares topic coverage
- Histopathological Validation of Clinical Palpation vs. Ultrasonography for Cervical Lymphadenopathy in Oral Squamous Cell Carcinoma: An Ambi-directional Cohort of 1,690 Nodes from Rural Karnataka, India — shares topic coverage
- Expression of ITG β-1, MMP9 and Vimentin in Oral Squamous Cell Carcinoma – A Real Time PCR Based Approach — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.