Association between Follicle Stimulating Hormone Receptor (FSHR) Polymorphism and Polycystic Ovary Syndrome among Egyptian Women
A. F. Abdel-Aziz, A. M. A. El-Sokkary, A. A. El-Refaeey, H. G. Osman, M. El-Sokkary, Rasha A. El-Saeed
International Journal of Biochemistry Research & Review · pp. 198–206 · Published 6 Dec 2014
10.9734/IJBCRR/2015/13896Abstract
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and the criteria are specified by common complex genetic hyperandrogenism, oligomenorrhea or amenorrhea and polycystic ovary morphology. It is a leading cause of female infertility. The prevelance of PCOS among reproductive age women has been estimated to be 4-12%. The association between PCOS and FSH receptor (FSHR) polymorphism attracts wide attention. The aim of the present study was to evaluate whether polymorphism of FSHR at Ala307Thr codon is associated with PCOS and with clinical features of PCOS patients in Egypt. Results: PCOS patients (n=64) and control subjects (n=65) in the reproductive age were recruited from the outpatient clinic of Obstetrics and Gynecology Department, Mansoura University, Egypt. The Ala307Thr polymorphism in FSHR, and the frequency of respective genotypes was studied and statistical analysis was performed. We found that the heterozygote Ala/Thr genotype was associated with PCOS (64.1%, OR=2.68, CI=0.97, P= 0.033) compared with controls. Conclusion: The variant of Ala307Thr polymorphism of FSHR was associated with PCOS but it may be related to high total testosterone levels. In addition the FSHR polymorphism was not associated with either luteinizing hormone or follicular stimulating hormone. The present study suggests that the variant of the FSHR gene may act as a causative factor of PCOS in Egyptian women.
References (32)
- 1 The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria [DOI]
- 2 Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome [DOI]
- 3 Body fat distribution and noncommunicable diseases in populations: overview of the 2008 WHO Expert Consultation on Waist Circumference and Waist–Hip Ratio [DOI]
- 4 MECHANISMS IN ENDOCRINOLOGY: Genetics of FSH action: a 2014-and-beyond view [DOI]
- 5 Mutations and polymorphisms in FSH receptor: functional implications in human reproduction [DOI]
- 6 Polycystic ovary syndrome and impact on health [DOI]
- 7 Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome [DOI]
- 8 An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance [DOI]
- 9 Normative Data for Adrenal Steroidogenesis in a Healthy Pediatric Population: Age- and Sex-Related Changes after Adrenocorticotropin Stimulation* [DOI]
- 10 Current Concepts of Follicle-Stimulating Hormone Receptor Gene Regulation1 [DOI]
- 11 Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome [DOI]
- 12 Two FSHR variants, haplotypes and meta-analysis in Chinese women with premature ovarian failure and polycystic ovary syndrome [DOI]
- 13 Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome [DOI]
- 14 Screening of FSH receptor gene in Argentine women with premature ovarian failure (POF) [DOI]
- 15 Polycystic Ovary Syndrome in the Adolescent [DOI]
- 16 Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function [DOI]
- 17 FSH-receptor Ala307Thr polymorphism is associated to polycystic ovary syndrome and to a higher responsiveness to exogenous FSH in Italian women [DOI]
- 18 Association of Follicle-Stimulating Hormone Receptor Polymorphisms with Ovarian Response in Chinese Women: A Prospective Clinical Study [DOI]
- 19 Frequency distribution of polymorphisms in the FSH receptor gene in infertility patients of different ethnicity [DOI]
- 20 Pharmacogenetics of follicle-stimulating hormone action [DOI]
- 21 FTOGene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women [DOI]
- 22 Radioimmunoassay for human follicle—stimulating hormone: physiological studies [DOI]
- 23 Association between FSHR polymorphisms and polycystic ovary syndrome among Chinese women in north China [DOI]
- 24 Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women [DOI]
- 25 Single-nucleotide polymorphisms in the FSH receptor gene and ovarian performance: Future role in IVF [DOI]
- 26 Prevalence of metabolic syndrome in the family members of women with polycystic ovary syndrome from North India [DOI]
- 27 Managing Polycystic Ovary Syndrome: A Cognitive Behavioral Strategy [DOI]
- 28 Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis [DOI]
- 29 Frequency distribution of polymorphisms in the FSH receptor gene in infertility patients of different ethnicity [DOI]
- 30 Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome [DOI]
- 31 STUDY ON FOLLICLE STIMULATING HORMONE RECEPTOR GENE POLYMORPHISMS IN SOUTH INDIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME [DOI]
- 32 Measurement of Early Chorionic Activity with a Radioimmunoassay Specific for Human Chorionic Gonadotropin Following Spontaneous and Induced Ovulation [DOI]
Cited by 10
Priya Sharma, Abhilash Kumar Singh, Sabyasachi Senapati · Metabolic Syndrome and Related Disorders · 2024
· American Journal of BioMedicine · 2019
Nermin Seda Ilgaz, Oya Sena Erdogan Aydos, Aynur Karadag · Journal of Assisted Reproduction and Genetics · 2015
Nishu Sekar, Samiksha Yeole, Rashmi Pradeep · IOP Conference Series: Materials Science and Engineering · 2017
Ankita Wal, Biswajit Dash, Vaibhav Jaiswal · Targeting Angiogenesis, Inflammation, and Oxidative Stress in Chronic Diseases · 2024
Showing 5 of 10 known citations — external sources report more than can currently be individually listed.
Related research
- Investigation of Protamine Genes (PRM1, PRM2) Polymorphism and Its Impact on Sperm Toroid Integrity in Males from Ahmedabad (India) — shares topic coverage
- Absence of β-tubulin SNPs Associated with Drug Resistance in Ascaris lumbricoides Infections of School-Age Children in Bungoma County, Kenya — shares topic coverage
- Differences of Polycystic Ovary Syndrome (PCOS) Effects among Asian and Caucasian Women — shares topic coverage
- ‘Efficacy of GLP-1 Receptor Agonists’ in Hypertriglyceridemia: A Systemic Review and Meta Analysis — shares topic coverage
- Effects of Ovarian Steroids on Osteoblast Viability and Mineralization — shares topic coverage
Article metrics
Real usage data collected on this platform.
85
Page views
0
PDF downloads
39
Outbound clicks
10
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.