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Research Article Open access CC BY 4.0

Assessment of Some Biochemical Changes in Wistar Rats Following Administration of Three Polyherbal Preparations Repurposed for COVID-19

Kennedy Iliya Amagon, Bukata Bayero Bukar, Jacob Adegboyega Kolawole, Kakjing Dadul Falang, Ukpe Ajima, James Garba Damen, Yusuf Amuda Agabi, Richard Joseph Kutshik, Ishaya Yohanna Longdet, Simji Samuel Gomerep, Ismaila Shittu, Stephen Daniel Davou, Noel Nen’man Wannang

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 54–60 · Published 14 Dec 2020

10.9734/jamps/2020/v22i930194

Abstract

Background and Aims: The current pandemic known as Coronavirus Disease-19 (COVID-19) is a significant public health menace. Currently, there is no specific treatment for this disease, although some medicinal agents are under investigation. Some published articles have reported Severe Acute Respiratory Distress Syndrome Coronavirus-2 (SARS CoV-2) involvement in other organs, including the liver and kidneys, which can impair the metabolism and excretion of the medications taken to treat the disease. This study evaluated the effects of 3 herbal mixtures on some biochemical parameters of the liver and kidney of laboratory animals. Methods: Liver enzymes such as serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin and total serum protein were quantified. Urea, creatinine and bilirubin (total and direct) were also evaluated. These parameters were determined for all three polyherbal combinations (CoV Pla-1, CoV Pla-2, CoV Pla-3). Results: The extracts did not produce any mortality up to 5000 mg/kg per oral. Results showed that the polyherbal extracts (CoV Pla-1, CoV Pla-2 CoV Pla-3) did not cause any significant changes in ALT, AST, ALP, compared to control. The mean values of urea showed an insignificant (P>0.05) decrease across all test doses in the three extracts, compared to the control. In the current   study, the mean creatinine concentration showed slight decrease across all three extracts. Total protein was observed to be lower in CoV Pla-1 and CoV Pla-2, and increased in CoV Pla-3,    though these changes were not statistically significant. Serum albumin decreased at the low   and intermediate doses for the three polyherbal extracts in an insignificant manner compared to control. Conclusion: The results obtained in this study indicate that the extracts did not cause  significant changes in biochemical parameters evaluated and support their use in the treatment of Covid-19.

Covid-19 polyherbal combinations SARS CoV-2 serum enzymes.

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