Assessment of Blood Ferritin and Vitamin D Levels in Patients Suffering from Myocardial Infarction to Determine Their Clinical Significance and Prognostic Value of Hematological Markers in Acute Myocardial Infarction: A Meta-analysis

Abstract

Acute myocardial infarction (AMI) is a major cardiovascular illness that causes death as well as disability on a global scale. Understanding how vitamin D contributes to the pathophysiology, epidemiology, and prevention of cardiovascular disease (CVD) is still of interest. Although vitamin D has been recognised as a potentially significant CVD marker, it is still unclear how vitamin D deficiency causes endothelial dysfunction, which in turn causes myocardial infarction and stroke. This review's objective is to present an updated analysis of the research on the fundamental science underlying vitamin D's potential effects on the cardiovascular system. Ferritin is associated with unfavourable outcomes in individuals with a variety of clinical diseases, assessment for ferritin may be beneficial. Our goal was to carry out the first comprehensive analysis of the correlation between elevated ferritin levels and worse cardiovascular outcomes in individuals suffering from acute myocardial infarction (AMI).In patients with AMI, both low and high ferritin levels were linked to how long they spent in the hospital during their hospital stay and at longer follow-up. Ferritin assessment is a straightforward test that may be used to identify AMI patients at high risk who may benefit from more frequent follow-up and specific therapy. Regarding the state of modern treatments for AMI and heart failure, these findings ought to be validated by extensive clinical trials. This review also discuss the role of hematological indices: Total white blood cells (WBC) count, neutrophil to lymphocyte ratio (NLR),eosinophil leucocyte ratio, diffrential lecocyte count, absolute values of WBCs, red cell distribution width (RDW), and platelet indices, such as , mean platelet volume (MPV),platelet to lymphocyte ratio (PLR) and platelet distribution width (PDW) etc and its diagnostic and prognostic value in MI and its complications which may shed fresh light on developing new treatment plans on MI patients and help doctors in the diagnosis and prognosis  with or without complications.