Assessment of Anatomical and Histological Changes in Splenomegaly Due to Liver Cirrhosis by Use of Sharpunkha: An Experimental Study

Abstract

Splenomegaly is the disease commonly affecting normal anatomy and histology of spleen. It remains undetectable and worsens as the time passes and person suffers from stressful life. It leads as a consequence of many diseases. One of them important disease is Liver cirrhosis. In Ayurveda also relation of liver and spleen is depicted emphatically. Yakrita and Pleeha are described as Moolsthana of Raktvaha Strotasa and site of Raktadhara Kala and which are the important aspects of Ayurvedic Rachana Sharir. The facts regarding liver cirrhosis and splenomegaly are very much serious which has provoked us to think about to detail study of splenomegaly due to liver cirrhosis. There is no absolute treatment of splenomegaly till date. In Bhavprakasha, there is reference regarding Sharpunkha (Tephrosia Purpurea)that it is “Pleehashatru” showing that it might acts on the spleen and cures splenic disorders. But there is evidence base gap regarding efficacy of Sharpunkha on Splenomegaly. Kshara or Churna of Sharpunkha Panchanga are described as its useful preparations. There is no work done till date showing action of Sharpunkha Panchanga Kshara or Churna on Splenomegaly and there is deficit of study showing alteration in anatomy and histology of spleen affecting due to splenomegaly by using Sharpunkha. So it is needed to study effect of both Kshara and Churna separately and compare them so that we can use Panchanga Kshara or Panchanga Churna with more specificity. It can be a new modality in the field of Ayurvedic science to study effect of Sharpunkha Panchanga Kshara and Panchanga Churna on Splenomegaly showing changes in anatomy and histology of spleen affecting due to splenomegaly. Also with the help of that “Pleehghan Prabahva” and classical assert as “Pleehashatru” of Sharpunkha can be proven.