Effects of Tramadol on Fertility Hormones (Follicle Stimulating Hormone, Leutinizing Hormone, Prolactin, Testosterone, Estrogen and β-HCG) in Laboratory Rabbits

Abstract

Drug abuse in Nigeria has been indicated to be on the rise in recent years. The use of hard drugs and misuse of prescription drugs for nonmedical purposes cuts across all strata, especially the youths. Tramadol (2[(Dimethylamin) methyl]-1-(3-methoxyphenyl)cyclohexanol) is known for its analgesic potentials. This potent opioid pain killer is misused by Nigerian youths, owing to its suspicion as sexual performance drug. This study therefore is aimed at determining the effect of tramadol on hormone levels its improved libido properties and possibly fertility. Twenty seven (27) European rabbits weighing 1.0 to 2.0 kg were used. Animals were divided into four major groups consisting of male and female control, and male and female tramadol treated groups. Treated groups were further divided into oral and intramuscular (IM) administered groups. Oral groups were administered 25 mg/kg b.w. of tramadol per day while the IM groups received 15 mg/kg b.w. per day over a period of thirty days. Blood samples were collected at the end of the experiment for progesterone, testosterone, estrogen (E2), luteinizing hormone, follicle stimulating hormone (FSH), β-human chorionic gonadotropin and prolactin estimation. Tramadol treated groups were compared with control groups at the end of the study, as well as within group comparison was done. From the results, FSH was found to be significantly reduced (p<0.05) while LH increased significantly (p<0.05).  A decrease was observed for testosterone (p<0.001), and estrogen, FSH, progesterone also decreased (p<0.05). Significant changes weren’t observed when IM groups were compared with oral groups. This study does not support an improvement of libido by tramadol, though its possible usefulness in the treatment of premature ejaculation may have been established, but its capabilities to induce male and female infertility is still in doubt.