Antioxidant, Antimicrobial, Cytotoxic, Anticholinesterase, Antityrosinase Activities and Characterisation of Volatile Compounds of Verbascum oocarpum by SPME and GC-FID/MS
Seyda Kanbolat, Nuriye Korkmaz, Sıla O. Sener, Merve Badem, Nevin Ulas Colak, Mahmoud Abudayyak, Rezzan Aliyazicioglu, Ufuk Ozgen, Ali Kandemir, Sengul Alpay Karaoglu
Journal of Pharmaceutical Research International · pp. 1–12 · Published 19 Nov 2018
10.9734/JPRI/2018/45242Abstract
The objective of present study was to specify the antioxidant, antimicrobial, cytotoxic, anticholinesterase, and antityrosinase activities of Verbascum oocarpum Murb., together with its volatile components. The methanolic and aqueous extracts of aerial parts of V. oocarpum indicated substantial antioxidant activity derived from benzoic acid, sinapic acid, and quercetin compounds. The methanolic extract displayed moderate antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, and Mycobacterium smegmatis. It also exhibited a higher IC50 value on tyrosinase than kojic acid, and lower acetylcholinesterase and butyrylcholinesterase inhibitor activities than galantamin. MTT analysis revealed that high concentrations of V. oocarpum extract can result in cytotoxicity, with an IC50 of 0.444 mg/mL. Common volatile components included pentadecane, hex-2(E)-enal, limonene, phenylacetaldehyde, isophorone, 1-methoxy-4-(2-propenyl)-benzene, 5,6,7,7a-tetrahydro-4,4,7a-trimethyl-2(4h)-benzofuranone and hexadecane. V. oocarpummay be of potential benefit to the food, cosmetical, and pharmaceutical sectors owing to its potent anticholinesterase, antioxidant, and antimicrobial activities, volatile components, and limited cytotoxicity.
Cited by 10
Osman Şahin, Şeyda Kanbolat, Nevin Ulaş Çolak · Chemistry & Biodiversity · 2024
Mohamed Ouknin, Yin Yang, Jean Costa · Journal of Biologically Active Products from Nature · 2022
Yusuf ALAN, Züleyha ALMAZ · Bitlis Eren Üniversitesi Fen Bilimleri Dergisi · 2022
Simone Angeloni, Gokhan Zengin, Kouadio Ibrahim Sinan · Industrial Crops and Products · 2021
Rao Anum Rehman Khan, Samina Afzal, Hanan Y. Aati · Heliyon · 2024
Sıla SENER, Şeyda KANBOLAT, Nevin ULAŞ ÇOLAK · Trakya University Journal of Natural Sciences · 2023
Merve Badem, Seyda Kanbolat, Nevin Ulaş Çolak · Food Bioscience · 2024
Samed Şimşek · Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi · 2025
Md. Anzarul Haque, Mandeep Singh, Manish Kumar Tripathi · Proteins: Structure, Function, and Bioinformatics · 2022
Showing 9 of 10 known citations — external sources report more than can currently be individually listed.
Related research
- In vitro Antioxidant and Anticancer Activity of Cyanobacteria — shares topic coverage
- Review: Parkia speciosa as Valuable, Miracle of Nature — shares topic coverage
- A Selective Review of Lipid Autoxidation and Rancidity, Antioxidants, and Dithiooxamide — shares topic coverage
- Antioxidant and Haemato-Biochemical Enhancing Properties of Daucus carota in Male Wistar Rats Toxicated with Lead Chloride — shares topic coverage
- Radical Scavenging Capacity and Efficacy of Myristica fragrans (Nutmeg) Metabolites on Cladosporum herbarum of Food Origin — shares topic coverage
Article metrics
Real usage data collected on this platform.
8
Page views
0
PDF downloads
0
Outbound clicks
10
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.