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Research Article Open access CC BY 4.0

Antioxidant, Anti-inflammatory and Cytotoxic Properties of Cancerol S, A Blend of Medicinal Plants, on Cancerous Cells in Culture

Marc Donald Wilfried Adico, Bagora Bayala, Florencia Wendkuuni Djigma, Bapio Valerie Elvira Jean Telesphore Bazié, Paul Darga, Jean-Marc Lobaccaro, Jacques Simporé

Annual Research & Review in Biology · pp. 87–98 · Published 14 Aug 2024

10.9734/arrb/2024/v39i82112

Abstract

Aims: To evaluate in vitro the properties of a blend of medicinal plants called Cancerol S through its antioxidant, anti-inflammatory and cytotoxic potential on cancerous cells in culture. Methodology: High-performance thin-film chromatography (HPTLC) and the assay test were used for phytochemical screening of Cancerol S. The antioxidant power of Cancerol s was evaluated by free radical inhibition tests (DPPH and ABTS) and the Iron III Reduction Power (FRAP). The inhibition tests of 15-LOX (15-lipoxygenase) and COX1/COX2 (cyclooxygenases) were used to evaluate the anti-inflammatory capacity of Cancerol S.  Results: The total polyphenols and flavonoids content of the extract were respectively 115.6 ± 0.1 mg EAG/g and 43.4 ± 0.1 mg EQ/g dry extract. The extract showed excellent antioxidant activity, with inhibition of DPPH (EC50 = 8.3 ± 0.7 μg/mL) and ABTS (EC50 = 36.0 ± 1.1 μg/mL), and also reduced ferric ion Fe3+ (2.67 ± 0.1 mmol EAA/g extract). In addition, the extract moderately inhibited 15-LOX, COX-1 and COX-2. The HeLa cell line of cervical cancer was more sensitive to Cancerol S (EC50 = 84.6 ± 5.2 μg/mL) than the prostate cancer cell line DU 145 (EC50 = 140.7 ± 7.8 μg/mL). Conclusion: These properties give a rational basis for the use of Cancerol S in traditional medicine in Burkina Faso.

Cytotoxic antioxidant anti-inflammatory Cancerol S

References (40)

  1. 1 Antioxidant activity applying an improved ABTS radical cation decolorization assay [DOI]
  2. 2 The correlation coefficient: Its values range between +1/−1, or do they? [DOI]
  3. 3 Cyclooxygenases: structural and functional insights [DOI]
  4. 4 Plant-derived anticancer agents: A green anticancer approach [DOI]
  5. 5 Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts [DOI]
  6. 6 Tumor microenvironment: recent advances in various cancer treatments. [DOI]
  7. 7 Antioxidant activities of ethanolic extracts from the twigs of Cinnamomum osmophloeum [DOI]
  8. 8 Antioxidant activity of Paraguayan plant extracts [DOI]
  9. 9 Inhibitors of 15-Lipoxygenase from Orange Peel [DOI]
  10. 10 Cyclooxygenases and lipoxygenases in cancer [DOI]
  11. 11 Antioxidant, anti‐inflammatory, and enzyme inhibitory activity of natural plant flavonoids and their synthesized derivatives [DOI]
  12. 12 Effect of pre-treatment and different drying methods on the physicochemical properties of Carica papaya L. leaf powder [DOI]
  13. 13 Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection [DOI]
  14. 14 Correlation between cytotoxicity in cancer cells and free radical‑scavenging activity: In�vitro evaluation of 57 medicinal and edible plant extracts [DOI]
  15. 15 Modification of Semi-Analytical Method Applied System of ODE [DOI]
  16. 16 Anticancer activity evaluation of the Solanum glycoalkaloid solamargine [DOI]
  17. 17 Action of solamargine on human lung cancer cells – enhancement of the susceptibility of cancer cells to TNFs [DOI]
  18. 18 Inhibitory Properties of Phenolic Compounds Against Enzymes Linked with Human Diseases [DOI]
  19. 19 In vitro antioxidant and anticancer effects of solvent fractions from prunella vulgaris var. lilacina [DOI]
  20. 20 Antibacterial, antiproliferative and antioxidant activity of leaf extracts of selected Solanaceae species [DOI]
  21. 21 Comprehensive approaches on the chemical constituents and pharmacological properties of flowers and leaves of American basil (Ocimum americanum L) [DOI]
  22. 22 Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway [DOI]
  23. 23 Anticancer activity and phytochemical composition of wild Gundelia�tournefortii [DOI]
  24. 24 Medicinal plants used in management of cancer and other related diseases in Woleu-Ntem province, Gabon [DOI]
  25. 25 Oxidative Stress and Inflammation Can Fuel Cancer [DOI]
  26. 26 Essential Oils of Ocimum basilicum L. and Ocimum americanum L. from Djibouti: Chemical Composition, Antimicrobial and Cytotoxicity Evaluations [DOI]
  27. 27 Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy [DOI]
  28. 28 Natural Inhibitors against Potential Targets of Cyclooxygenase, Lipoxygenase and Leukotrienes [DOI]
  29. 29 Anticancer properties of recipes derived from nigeria and african medicinal plants on breast cancer cells in vitro [DOI]
  30. 30 Contribution of Sub-Saharan African medicinal plants to cancer research: Scientific basis 2013–2023 [DOI]
  31. 31 Phytochemical Screening and Biological Activities of Combretum adenogonium Leaves Extracts [DOI]
  32. 32 Study of the antibacterial capacity of extracts of Solanum incanum L., (Solanaceae) traditionally used for the management of avian cholera in rural areas of Burkina Faso [DOI]
  33. 33 Genetic Predisposition to Cancer [DOI]
  34. 34 Anticancer Activity of Combretum fragrans F. Hoffm on Glioblastoma and Prostate Cancer Cell Lines [DOI]
  35. 35 In vitro cytotoxicity of recipes derived from Nigerian medicinal plants (NMPs) on breast cancer cells
  36. 36 The Impact of the COVID-19 Pandemic on Cancer Mortality in Pennsylvania: A Retrospective Study with Geospatial Analysis [DOI]
  37. 37 Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis [DOI]
  38. 38 Combretum Adenogonium Induce Anticancer and Antioxidant Effects in Prostate Cancer Cell Line [DOI]
  39. 39 Network target for screening synergistic drug combinations with application to traditional Chinese medicine [DOI]
  40. 40 Antioxidant and antibacterial activities of polyphenols from ethnomedicinal plants of Burkina Faso [DOI]

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