Antifungal Effect of 7-hydroxycitronellal against Candida albicans Strains
Heloísa Mara Batista Fernandes de Oliveira, Abrahão Alves de Oliveira Filho, José Pinto de Siqueira Júnior, Edeltrudes de Oliveira Lima
International Journal of TROPICAL DISEASE & Health · pp. 1–5 · Published 7 Oct 2015
10.9734/IJTDH/2016/19329Abstract
Monoterpenes, the main constituents of essential oils, are associated with antifungal, analgesic, antiepileptic, anti-inflammatory, anxiolytic and gastroprotective activities. The aim of this study was to evaluate the antifungal effects of the monoterpene 7-hydroxycitronellal against five Candida albicans strains using microdilution method. All the strains were obtained from the Laboratory of Mycology collection. Nistatin (100 UI/mL) was used as the standard drug. The monoterpene showed strong antifungal activity with MIC50 and MFC50 values of 256 and 512 µg/mL respectively. The results showed fungicidal potential of 7-hydroxycitronellal against C. albicans strains.
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