Antifungal Activity of Phytochemicals against Species of Cladosporium and Cladophialophora

Abstract

Cladosporium species are ubiquitous, saprobic dematiaceous fungi, associated with human and animal opportunistic infections. Cladosporium has been known to be one of the most airborne fungi causing respiratory allergies diseases, particulary asthma and rhinitis. Antifungal compounds of natural origin, such as terpenes, have received much attention in recente times. They are a promising therapeutic tool for treating fungal infections, and are known for their antimicrobial properties.  Aims: In this context, the present study aims to evaluate the in vitro antifungal activity of eight phytochemicals commonly found in Melissa officinalis L. essential oil (citral, (-) citronelal, (+) citronelal, β-caryophyllene, geraniol, linalool, β-cymene, α-pinene) against ten species of Cladosporium and Chadophialophora. Methodology: Antifungal susceptibility testing was performed with the phytochemicals at a concentration of 1.024 µg/mL. Microbiological screening was performed based on the broth microdilution technique. Results: Through analysis of results, it is observed that citral showed the best activities of the as species of Cladosporium studied.  Conclusion: Citral representing a new possibility in the arsenal of products for treatment of fungal infections caused by these fungi.