Antidiabetic and Antiinflammatory Potentials of Sida Acuta Leaf Ethanolic Extract

Abstract

Introduction: Sida acuta is known as common wireweed, and has a pantropical distribution. Antioxidants fight against free radicals and prevent a variety of diseases. Anti Inflammatory reaction is the ability of a substance to reduce swelling or inflammation. Antidiabetic substances are defined as agents which help in maintaining the level of glucose in the blood. Aim: Present study was aimed at assessing the in vitro antidiabetic and antiinflammatory potentials of Sida acuta leaf ethanolic extract.  Methods: Sida acuta was purchased and its ethanolic extract was prepared. Protein denaturation inhibition, DPPH radical scavenging, alpha amylase and alpha glucosidase inhibitory assays were carried out in order to check in vitro antiinflammatory, antioxidant and antidiabetic activity spectrophotometrically..  The data were analysed using one-way analysis of variance  (ONE-WAY ANOVA) to see the statistical significant among the different concentrations of extract. P<0.05 levels were considered as statistical significance. Results: The extract of Sida acuta was compared with aspirin and an antiinflammatory reaction was analysed. Statistically significant at the levels of p < 0.05.The extract proved to contain antiinflammatory and antioxidant reactions. Alpha amylase and alpha glucosidase activity was analysed by comparing the extract with metformin. Conclusion: Sida acuta can be used for the management and treatment of various diseases and disorders. It can be used for the treatment of diabetes and cancer.