Antibiotic Sensitivity Profile of Escherichia coli Strains isolated from Urinary Tract Infections at the Fann University Hospital Center

Abstract

This was a retrospective descriptive and analytical study conducted in 2022 at the Bacteriology-Virology Laboratory of the Fann National University Hospital Center, with the objective of determining the antibiotic sensitivity profile of uropathogenic E. coli strains. The data were entered into Excel 2013 and analyzed using IBM SPSS 25 software. We noted poor bêta-lactam activity with a broad-spectrum bêta-lactamase (ESBL) production rate of 46%. Imipenem retained good activity with 98% of strains sensitive. The sensitivity rate to fluoroquinolones was variable with average activity: ciprofloxacin (54.1%), levofloxacin (52.3%), norfloxacin (52.5%). Strong resistance was noted with cotrimoxazole, with only 24.4% of strains being sensitive. The activity of aminoglycosides was good : amikacin (90.4%), gentamicin (71.3%), tobramycin (70.1%). Good sensitivity of strains was also noted for nitroxoline (88.8%) and fosfomycin (74.0%). The study of the sensitivity of ESBL-producing strains shows better activity of imipenem (94.4%), amikacin (80.6%), nitroxoline (87.8%), and fosfomycin (77.1%) with high resistance to quinolones and cotrimoxazole.