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Research Article Open access CC BY 3.0

Anti HIV-1 Activity of the Crude Extracts of Guaiacum officinale L. (Zygophyllaceae)

Henry I. C. Lowe, Ngeh J. Toyang, Alonso Heredia, Charah T. Watson, Joseph Bryant

European Journal of Medicinal Plants · pp. 483–489 · Published 16 Jan 2014

10.9734/EJMP/2014/7343

Abstract

Aim: Jamaica is rich in medicinal plants.  Guaiacum officinale is the “National Flower”, with reported uses in folk medicine for the treatment of various conditions including inflammation.  In our search for plants with anticancer and anti-infective properties, we evaluated Guaiacum officinale for activity against HIV-1. Methodology: The leaf, seed and twig extracts of G. officinale were screened for anti HIV-1 properties in primary peripheral blood mononuclear cells (PBMCs) infected with the reference HIV-1 BaL strain. Results: All the tested extracts inhibited HIV-1 p24 production by infected cells, with EC50 concentrations of 22.35µg/ml, 23.42µg/ml and 25.04µg/ml, respectively for the leaf, seed and twig extracts. As comparison, Betulinic acid had an EC50 value of 27.50µg/ml. The tested extracts had IC50/EC50 selectivity index (SI) values of ≥ 3, which compared favorably to Betulinic acid SI value of 1.09. Conclusion: The results of this study suggest that extracts of G. officinale may provide leads for the discovery of new drug agents against HIV-1.

Guaiacum officinale anti HIV-1 Jamaica medicinal plant

References (23)

  1. 1 The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection [DOI]
  2. 2 The biological action of saponins in animal systems: a review [DOI]
  3. 3 Anti-AIDS Agents, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzigium claviflorum, and the Anti-HIV Activity of Structurally Related Triterpenoids [DOI]
  4. 4 Medicinal Plants: Historical and Cross-Cultural Usage Patterns [DOI]
  5. 5 Transmission, acute HIV-1 infection and the quest for strategies to prevent infection [DOI]
  6. 6 Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents [DOI]
  7. 7 Anti-HIV Michellamines from Ancistrocladus korupensis [DOI]
  8. 8 In vitro anti-HIV activity of five selected South African medicinal plant extracts [DOI]
  9. 9 The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression [DOI]
  10. 10 The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression [DOI]
  11. 11 Natural Product-Based Anti-HIV Drug Discovery and Development Facilitated by the NCI Developmental Therapeutics Program [DOI]
  12. 12 Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis [DOI]
  13. 13 Plants as a source of anti‐cancer and anti‐HIV agents [DOI]
  14. 14 Anti-HIV activity of Indian medicinal plants [DOI]
  15. 15 Anti-inflammatory Activity of Polygonum bistorta, Guaiacum officinale and Hamamelis virginiana in Rats [DOI]
  16. 16 Anti-HIV-1 efficacy of extracts from medicinal plants [DOI]
  17. 17 Traditional Botanical Remedies on a Small Caribbean Island: Middle (Grand) Caicos, West Indies [DOI]
  18. 18 Saponins from the leaves ofGuaiacum officinale [DOI]
  19. 19 Guaiacin A and B from the Leaves ofGuaiacum officinale [DOI]
  20. 20 Natural Product-Based Anti-HIV Drug Discovery and Development Facilitated by the NCI Developmental Therapeutics Program. [DOI]
  21. 21 Triterpenoid saponin from the bark of Guaiacum Officinale L. [DOI]
  22. 22 A New Bidesmoside Saponin from the Bark of Guaiacum officinale
  23. 23 HIV: Cell Binding and Entry [DOI]

Cited by 11

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In vivo neuroprotective effect of Guaiacum officinale leaf extracts in scopolamine-induced cognitive impairment model

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Total Phenolic Contents and Free Radical Scavenging Activity of Guaiacum officinale L. Extracts

Suthira Maneechai, Vachiraporn Pikulthong · Pharmacognosy Journal · 2017

Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds

Henry Lowe, Blair Steele, Joseph Bryant · Molecules · 2021

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