Anti-Arthritic Effect of the Aqueous Extracts of the Roots and Barks of Gossypium herbaceous in Complete Freund’s Adjuvant Induced Arthritis  in Female Wistar Rats

Abeng Edoa Catherine; Youovop Janvier; Fonkoua Martin; Takuissu Guemto Guy; Amamba Akamba Dupon; Nanhah Jules Vidal; Fopa Lambou Grace; Oben Enyong Julius

doi:10.9734/jocamr/2023/v22i3460

Research Article Open access CC BY 4.0

Anti-Arthritic Effect of the Aqueous Extracts of the Roots and Barks of Gossypium herbaceous in Complete Freund’s Adjuvant Induced Arthritis in Female Wistar Rats

Abeng Edoa Catherine, Youovop Janvier, Fonkoua Martin, Takuissu Guemto Guy, Amamba Akamba Dupon, Nanhah Jules Vidal, Fopa Lambou Grace, Oben Enyong Julius

Journal of Complementary and Alternative Medical Research · pp. 28–37 · Published 17 Jun 2023

10.9734/jocamr/2023/v22i3460

Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of one or more joints resulting to disability. Age (above 50 years) and life style are the main risk factors. In this study, we evaluated the effects of the aqueous extracts of the roots and barks of Gossypium herbaceum (G. herbaceous) in Complete Freund’s Adjuvant (CFA) induced rheumatoid arthritis in female wistar rats. Materials and Methods: In vitro anti-inflammatory tests were conducted through the inhibition of hemolysis and lipid peroxidation. An acute toxicity test of both extracts was done. 25 female Wistar rats were used. RA was induced in 20 rats (4 groups) by injecting CFA into the sub plantar region of the right hind paw of each rat. On day 25 of the experiment, the rats were sacrificed, and the sera were prepared for the evaluation of some inflammatory and biochemical parameters. The paws were dissected and kept for histological analyzes. Results: The extracts revealed anti-inflammatory activities in vitro, with a higher activity observed from the roots. Both extracts restored body weight and significantly reduced edema compared to the negative control group. The histological analyzes of the RA group revealed the presence of white blood cells in the synovial fluid and cartilage destruction as compared to the groups receiving roots’ aqueous extract and methotrexate. Both extracts significantly restored the levels of some inflammatory and biochemical parameters. Conclusion: Anti-inflammatory and biochemical tests showed that the aqueous extracts of the roots and barks of G. herbaceous are potentially effective in the management of RA.

Rheumatoid arthritis inflammation Gossypium herbaceum complete freund’s adjuvant

References (11)

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Abeng Edoa Catherine, Youovop Janvier, Fonkoua Martin, Takuissu Guemto Guy, Amamba Akamba Dupon, Nanhah Jules Vidal, Fopa Lambou Grace, Oben Enyong Julius (2023). Anti-Arthritic Effect of the Aqueous Extracts of the Roots and Barks of Gossypium herbaceous in Complete Freund’s Adjuvant Induced Arthritis in Female Wistar Rats. Journal of Complementary and Alternative Medical Research , 28–37. https://doi.org/10.9734/jocamr/2023/v22i3460

Affiliations

Abeng Edoa Catherine — Department of Biochemistry, Laboratory of Nutrition and Nutritional Biochemistry, The University of Yaoundé 1, Cameroon.
Youovop Janvier — Department of Biochemistry, Laboratory of Nutrition and Nutritional Biochemistry, The University of Yaoundé 1, Cameroon.
Fonkoua Martin — Department of Biochemistry, Laboratory of Nutrition and Nutritional Biochemistry, The University of Yaoundé 1, Cameroon.
Takuissu Guemto Guy — Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O Box: 13033, Yaounde, Cameroon.
Amamba Akamba Dupon — Department of Biochemistry, Laboratory of Nutrition and Nutritional Biochemistry, The University of Yaoundé 1, Cameroon.
Nanhah Jules Vidal — Department of Biochemistry, Laboratory of Nutrition and Nutritional Biochemistry, The University of Yaoundé 1, Cameroon.
Fopa Lambou Grace — Department of Biochemistry, Laboratory of Nutrition and Nutritional Biochemistry, The University of Yaoundé 1, Cameroon.
Oben Enyong Julius — Department of Biochemistry, Laboratory of Nutrition and Nutritional Biochemistry, The University of Yaoundé 1, Cameroon.

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