Anti – Androgenic Activity of Caesalpinia bonducella in Androgen-induced Polycystic Ovarian Syndrome Rats

Abstract

Aim:  Our goal was to use the androgen and anabolic steroid (AAS) Testosterone Propionate (TP) to create a novel animal model to study polycystic ovaries. Materials and Methods: Thirty albino female Wistar rats weighing 200 – 250 g were split into five groups with six rats in each group. Group I was treated as standard control, Group II was treated as the PCOS induced group, Group III was treated as a standard group, Clomiphene citrate (20 mg per kg body weight), intraperitoneally (I.P) along with a 4 mg TP injection intramuscularly (I.M) in an oily solution, Group IV was treatment control group treated with a hydro-alcoholic extract of Caesalpinia bonducella (CBHAE) at a dose of 200 mg per kg body weight. Group V was given CBHAE at 400 mg per kg of body weight. Blood collected from animals examined for hormonal parameters and ovaries is subjected to histopathological studies.  Results: There was a fall in testosterone volume and an increase in the efflux of female hormone constituents, which improved the ovarian development and helped to regulate menses. Conclusion: Significantly lower levels of Testosterone were produced as a result of the extract, which also showed superior anti-androgenic properties. However, additional intervention is recommended in order to investigate the therapeutic effect of Caesalpinia bonducella seed in further detail.