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Research Article Open access CC BY 4.0

Analyzing Different Acetyl Co-A Metabolizing Enzymes as Potential Drug Targets against Mycobacterium tuberculosis

Shamim Akhtar, Sheetal Singh, Santosh Kumar, Dhiman Sarkar

Microbiology Research Journal International · pp. 1–15 · Published 12 Sep 2015

10.9734/BMRJ/2015/19032

Abstract

Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for the deaths of million people around the globe. The scenario is worse than ever due to the emergence of drug resistant strains which are widely spread throughout the globe in much faster ways. To control this worst situation, we need to speed up the search for novel drugs which can specifically kill drug resistant bacteria in collaborative ways amongst academic, clinician and industry. Among different metabolic pathways, fatty acid synthesis pathway has always been a very attractive area for the drug target because of its crucial role during the infection and further in long term survival of pathogen inside the human host. In this review article, we analyzed the role of important and crucial enzymes, which are responsible for the influx and efflux of acetyl co-A substrate, a central hub of metabolites, as potential drug targets against M. tuberculosis.  

Tuberculosis Mycobacterium tuberculosis drug resistant M. tb drug discovery fatty acid metabolism acetyl Co-A.

References (33)

  1. 1 Mycobacterial persistence requires the utilization of host cholesterol [DOI]
  2. 2 High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism [DOI]
  3. 3 The Process of Structure-Based Drug Design [DOI]
  4. 4 Foamy macrophages and the progression of the human tuberculosis granuloma [DOI]
  5. 5 Triclosan: Applications and safety [DOI]
  6. 6 Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery [DOI]
  7. 7 Comprehensive Treatment of Extensively Drug-Resistant Tuberculosis [DOI]
  8. 8 Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations [DOI]
  9. 9 Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. [DOI]
  10. 10 Identification and Characterization of the First Class of Potent Bacterial Acetyl-CoA Carboxylase Inhibitors with Antibacterial Activity [DOI]
  11. 11 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis [DOI]
  12. 12 Drugs that Inhibit Mycolic Acid Biosynthesis in Mycobacterium tuberculosis [DOI]
  13. 13 Virulence of Mycobacterium tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes [DOI]
  14. 14 Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl‐CoA synthetase [DOI]
  15. 15 A Flavin-dependent Monooxygenase from Mycobacterium tuberculosis Involved in Cholesterol Catabolism [DOI]
  16. 16 4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo [DOI]
  17. 17 Adenylating Enzymes in Mycobacterium tuberculosis as Drug Targets [DOI]
  18. 18 Infections Caused by Mycobacterium tuberculosis in Recipients of Hematopoietic Stem Cell Transplantation [DOI]
  19. 19 Advances in Mycobacterial Isocitrate Lyase Targeting and Inhibitors [DOI]
  20. 20 Cholesterol Oxidase Is Indispensable in the Pathogenesis of Mycobacterium tuberculosis [DOI]
  21. 21 Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis [DOI]
  22. 22 ORF18-disrupted mutant of Comamonas testosteroni TA441 accumulates significant amounts of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid and its derivatives after incubation with steroids [DOI]
  23. 23 Nitrate reduction pathways in mycobacteria and their implications during latency [DOI]
  24. 24 Inhibitory activity of chlorogenic acid on enzymes involved in the fatty acid synthesis in animals and bacteria [DOI]
  25. 25 Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations [DOI]
  26. 26 Oxidation of Glucose and Fatty Acids to CO2
  27. 27 Diagnosis of drug-resistant TB and provision of second-line TB treatment in India: some ethical considerations [DOI]
  28. 28 The Citric Acid Cycle Oxidizes Two-Carbon Units
  29. 29 Crystal Structure of a Monomeric Thiolase-Like Protein Type 1 (TLP1) from Mycobacterium smegmatis [DOI]
  30. 30 Metabolic engineering of Escherichia coli: construction and characterization of a gltA (citrate synthase) knockout mutant.
  31. 31 Advances in the treatment of pulmonary tuberculosis.
  32. 32 Role of Malate Synthase and other Enzyme Inhibitors in Mycobacterium Tuberculosis: A Mini Review
  33. 33 The Essential guide to prescription drugs [DOI]

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