Analysis of the Anti-inflammatory and Antioxidant Potential of the Fractions Obtained From the Ethyl Acetate Partition of the Leaves of Diplopterys Pubipetala
Clarice Avelar Almeida, Flavia Dayrell Franca, Miriam Martins Chaves, Kamylla Teixiera Santos, Maria Clara Ferreira Santos, Elytania Veiga Menezes, Sandra de Sousa Araujo, Cleiber Lucan Alves Araujo, Vanessa de Andrade Royo
European Journal of Medicinal Plants · pp. 1–11 · Published 5 May 2022
10.9734/ejmp/2022/v33i530463Abstract
Aims: The objective of this work was to analyze the anti-inflammatory, cytotoxic and antioxidant activity of the fractions of ethyl acetate from the leaves of D. pubipetala. Methodology: Liquid-liquid partitioning was performed, the ethyl acetate partition was eluted in classical liquid chromatography, followed by thin layer chromatography. Antioxidant activity was performed by the DPPH photochlorimetric method and the levels of interleukin (IL‑6), tumor necrosis factor α (TNF‑α), interleukin-10 (IL-10) and nitric oxide (NO) were identified in supernatants of cell cultures. Results: Fractions F4, F5 and F10 showed antioxidant activity. The F10 fraction indicated efficient anti-inflammatory activity by the production of IL-10 and nitric oxides. Fractions F4, F5 and F9 stimulated the production of IL-6 and TNF-α. Conclusion: These results indicate a possible synergistic action of the extract and the partition of ethyl acetate, since after fractionation the potential presented in previous studies was lower.
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