Analysing the Role of Platelet Rich Plasma As Biological Stimulator for Cartilage Regeneration: An Experimental Study
Kuldeep Chhatbar, Sandeep Srivastava
Journal of Pharmaceutical Research International · pp. 177–183 · Published 29 Dec 2021
10.9734/jpri/2021/v33i63B35274Abstract
Background: In articular cartilage defects and degenerative cartilage lesions, platelet-rich plasma(PRP) is increasingly used. PRP is an autologous concentration of platelets containing a high number of factors which are responsible for growth. In the healing, recovery and acceleration of biochemical processes, these growth factors play a role in reducing the pain associated with joint injuries. The latest world research shows excellent results in reducing pain by using PRP and it has tremendous scope in reducing the knee pain as well as in regeneration of the articular cartilage. This study aims to analyse the effectiveness of Autologous PRP as biologic stimulator for Cartilage Regeneration in Rabbit Model. Method: This will be a prospective experimental study carried out on 10 rabbits at Animal House in JNMC, Wardha. Osteoarthritis will be induced in the rabbits by destruction of articular cartilage. Then platelet rich plasma therapy. Will be given to induce the regeneration of the cartilage. Expected Results: Evidence of regeneration of articular cartilage in rabbits with osteoarthritis through Platelet Rich Plasma Therapy.
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