An Evaluation of Anti Hyperlipidemic Activity of Bombax ceiba Leaves on Hyperlipidemic Rat Model

Abstract

Traditional medicine, as delineated by the World Health Organization, comprises the collective knowledge, skills, and practices rooted in cultural theories, beliefs, and experiences, and is extensively utilized for health maintenance and the treatment of physical and mental ailments. Hyperlipidemia, a prevalent metabolic disease frequently caused by the overconsumption of high-fat foods, presents significant health hazards. Although statins are the principal pharmaceutical intervention, their side effects and expense have stimulated the pursuit of better, natural options. Bombax ceiba, a medicinal herb historically employed in Asia for several therapeutic purposes, has recently garnered interest for its possible lipid-regulating capabilities. This study assessed the impact of an ethanolic extract of Bombax ceiba on lipid profiles in rats subjected to hyperlipidemia via a high-fat diet. The examination evaluated factors such as HDL, LDL, total cholesterol, triglycerides, SGPT, SGOT, urea, and creatinine. The results indicated that HDL and LDL levels did not produce statistically significant outcomes (p < 0.05). ANOVA analysis detected no statistically significant differences in total cholesterol levels among groups. Nonetheless, urea and creatinine concentrations in groups 5 and 6, which were administered Bombax ceiba extract at 600 and 900 mg/kg, respectively, exhibited statistically significant results (p < 0.05). Furthermore, the significant improvement in SGPT and SGOT levels in these groups (p < 0.05) indicates a promising enhancement in liver function. The observed significant difference in triglyceride levels (p < 0.05) between groups 5 and 6 further supports the dose-dependent lipid-lowering effects of the extract. These findings underscore the potential of Bombax ceiba as a natural therapeutic agent for managing hyperlipidemia. However, further research is needed to isolate active components and elucidate the underlying mechanisms to keep the audience engaged and interested.