An Assessment of Hepato-protective Activity of Hygrophila auriculata Root Extract against Hepatic Injured Rodent Model

Abstract

Liver is a crucial organ that is susceptible to several hepatotoxins causing hepato-toxicities. These days, medicinal plants have been considered to be more promising compared with the conventionally utilized medications for hepatic treatments. In light of the dire circumstances affecting worldwide currently, Hygrophila auriculata is a vital plant with an abundance of health advantages and hepatoprotective properties. In this experiment, carbon tetrachloride (CCl4) was utilized to cause hepatotoxicity in rats and this plant's anti-hepatotoxic activity was evaluated through assessing the outcomes of several parameters (Liver functioning tests, kidney functioning tests and lipid profiles). Subsequent research revealed that the plant may, to varying degrees and in a dependent way, successfully restore the disrupted pathological state to healthy status. To interpret statistical analysis, the "One-way Anova test" was conducted using the SPSS 16 software. In the case of SGPT, the medium and high dose produced statistically significant (p<0.05) outcomes as compared to the negative control group and for SGOT decrease in all three groups were non-significant (p>0.05). Then for creatinine levels, the outcome for medium, and high dosages were statistically significant (p<0.05) whereas in case of urea level only the high dose imparted significant (p<0.05) decrease. However, none of the dosages for total cholesterol and triglyceride level produced statistically significant (p<0.05) effects. Only in the medium and high doses, HDL levels improved statistically significantly (p<0.05) whereas only the high dosages reduced reduce the LDL quantity in the blood significantly (p<0.05). As a result, Hygrophila auriculata is thought to possess a significant capacity for liver protection and may serve as a more secure and effective substitute for the commercially available synthetic medication, silymarin. To sum up, additional research is required in the future before this appealing plant could get utilized in the arena of hepatotoxic treatments.