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An Assessment of Antihypertensive & Anti-hyperlipidemic Activity of Allium sativum and Rauwolfia serpentina in Hypertension and High Fat Induced Rat Model

Sanjida Jannath, Bushratul Jannat, Syeda Taarin Ishraat, Mehrab Sadat, Sayma Akter Nirzana, Md. Rafat Tahsin, Fahima Aktar, Jakir Ahmed Chowdhury, Shaila Kabir, Abu Asad Chowdhury, Md. Shah Amran

Asian Journal of Advanced Research and Reports · pp. 185–192 · Published 5 Oct 2023

10.9734/ajarr/2023/v17i11564

Abstract

Introduction: Hypertension (high blood pressure) is an increasingly important global medical and public health problem that is linked to a higher risk of developing cardiovascular disease. Researchers in both developed and developing nations have identified it as one of the most widespread diseases currently present. The investigators are focusing on plants for better, safer, more affordable, and more effective alternatives due to unwanted risks and negative effects of synthetic pharmaceuticals. Allium sativum possesses anticarcinogenic, antioxidant, antidiabetic, renoprotective, anti-atherosclerotic, antibacterial, antifungal, and antihypertensive properties while Rauwolfia serpentina is known to possess pharmacological actions such as hypnotic effect, sedative effect, antihypertensive activity, and anti hypercholesteremic activity. Methods: Sixty rats were divided into six groups, each containing ten rats. With the exception of the negative control group, rats from all groups were given 1% NaCI solution as water and high fat diet as food to induce hypertension. After that, among the six groups one group was treated with Allium sativum, one group with Rauwolfia serpentina and one with the mixture of Rauwolfia serpentina and Allium sativum. Results and Discussion: In case of lipid profile and blood pressure (systolic blood pressure, diastolic blood pressure, and mean blood pressure) both Rauwolfia serpentina and Allium sativum significantly (p<0.05) reversed disturbed pathological state, when compared with disease control group. However, Rauwolfia serpentina demonstrated the highest degree of activity for anti-hypertensive activity (Mean Blood Pressure 89.79±5.84 mmHg) and Allium sativum is more potent for controlling abnormal lipid profile (Total Cholesterol 125.39±5.59). Conclusion: Therefore, this study provides scientific evidence that Rauwolfia serpentina and Allium sativum have considerable anti-hypertensive and anti-lipidemic activities. More research needs to be done on these plants to isolate particular therapeutic constituents, so that it can be applied more precisely and accurately to mitigate the respective disease.

Hypertension Allium sativum Rauwolfia serpentine rat anti-hypertensive activity anti-lipidemic activity

References (18)

  1. 1 The World Health Report 2002 - Reducing Risks, Promoting Healthy Life [DOI]
  2. 2 Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review [DOI]
  3. 3 Prevalence and Associated Risk Factors of Hypertension: A Cross‐Sectional Study in Urban Varanasi [DOI]
  4. 4 Garlic and Cardiovascular Disease: A Critical Review [DOI]
  5. 5 Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance [DOI]
  6. 6 Medicinal Plants in the Treatment of Hypertension: A Review [DOI]
  7. 7 Reduction in arterial stiffness with angiotensin II antagonist is comparable with and additive to ACE inhibition [DOI]
  8. 8 An overview of the antifungal properties of allicin and its breakdown products – the possibility of a safe and effective antifungal prophylactic [DOI]
  9. 9 Plants-herbal wealth as a potential source of ayurvedic drugs
  10. 10 Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats [DOI]
  11. 11 Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats [DOI]
  12. 12 Adverse Drug Effects, Compliance, and Initial Doses of Antihypertensive Drugs Recommended by the Joint National Committee vs the Physicians' Desk Reference [DOI]
  13. 13 Allium sativum [DOI]
  14. 14 EFFECT OF RESERPINE ON THE 5‐HYDROXYTRYPTAMINE AND ADENOSINETRIPHOSPHATE OF THE DOG INTESTINAL MUCOSA [DOI]
  15. 15 Antihypertensive Treatment With Enrasentan (SB217242) in an Animal Model of Hypertension and Hyperinsulinemia [DOI]
  16. 16 Calcium Channel Blockers [DOI]
  17. 17 Antihypertensive Drugs [DOI]
  18. 18 PREVALENCE AND ASSOCIATED RISK FACTORS OF HYPERTENSION AND PRE-HYPERTENSION AMONG THE ADULT POPULATION: FINDINGS FROM THE DUBAI HOUSEHOLD SURVEY, 2019 [DOI]

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