Skip to content
Research Article Open access CC BY 4.0

Amelioration of Extra-articular Effects Associated with Rheumatoid Arthritis Using Anti-arthritic Herbal Formulations

Kemzi N. Elechi-Amadi, Ojoye N. Briggs, Boma H. Opusunju, Ebirien-Agana S. Bartimaeus, Edna O. Nwachuku

Journal of Complementary and Alternative Medical Research · pp. 11–20 · Published 2 Apr 2020

10.9734/jocamr/2020/v9i230137

Abstract

Aim: This study investigated the ability of some herbal formulations to ameliorate extra-articular effects of some herbal formulations used in the management of rheumatoid arthritis in Nigeria. Methodology: Forty-nine (49) female albino Wistar rats were used for this study. They were divided into seven groups: A, B, C, D, E, F and G of seven rats each, with Group A serving as negative control while Group B was a positive control. Groups B, C, D, E, F and G were induced with rheumatoid arthritis by injecting 0.1 ml of Complete Freund's Adjuvant into the right hind paw of each rat. The rats were treated with the standard drug and herbal formulations respectively for 28 days as follows: Group C (treated with a standard drug, Celebrex), Group D (treated with the herbal drug, Jointeez), Group E (treated with a herbal drug, Arthropower), Group F (treated with combination therapy of Jointeez and Celebrex) and Group G (treated with combination therapy of Arthropower and Celebrex). At the end of the 28-day treatment period, the rats were anaesthetized with chloroform and sacrificed through puncture of the jugular vein. Five millilitres (5 ml) of blood samples were put into plain bottles for the analysis of biochemical parameters and 3 ml into K3EDTA bottles for haematological analysis. The lipid parameters were analysed using Mindray autoanalyzer while haematological parameters were determined using Sysmex haematology auto analyzer. Results: Total cholesterol (p<0.001), HDL (p=0.005) and LDL (p=0.004) were significantly reduced in the treated rats compared to the positive control group. Conversely, Packed Cell Volume (p<0.001) and Haemoglobin levels (p<0.001) were significantly reduced in the positive control rats compared to the treated rats. However, Total WBC count was significantly higher in the positive control rats than in the treated rats (p=0.001). The combination therapies used in this study did not offer a significantly different therapeutic advantage over the monotherapies used. The herbal formulations gave therapeutic effects on the extra-articular effects similar to that obtained from the orthodox drug used in this study.  Conclusion: The herbal formulations can be used as alternative regimens for rheumatoid arthritis. It is recommended that herbal formulations be considered for integration into our healthcare system for the management of rheumatoid arthritis.

Anti-arthritic herbal formulation complete Freund’s adjuvant rheumatoid arthritis Nigeria.

References (23)

  1. 1 Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis [DOI]
  2. 2 Rheumatoid arthritis and cardiovascular disease [DOI]
  3. 3 Use of Biologics in Rheumatoid Arthritis: Current and Emerging Paradigms of Care [DOI]
  4. 4 Natural anti-inflammatory agents for pain relief [DOI]
  5. 5 Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders [DOI]
  6. 6 Systemic inflammation as a risk factor for atherothrombosis [DOI]
  7. 7 In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund's adjuvant (CFA)-induced arthritis in rats [DOI]
  8. 8 Gelam Honey Inhibits the Production of Proinflammatory, Mediators NO, PGE2 , TNF-α, and IL-6 in Carrageenan-Induced Acute Paw Edema in Rats [DOI]
  9. 9 Scientific Basis of Botanical Medicine as Alternative Remedies for Rheumatoid Arthritis [DOI]
  10. 10 Anemia of chronic disease: A unique defect of iron recycling for many different chronic diseases [DOI]
  11. 11 Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors [DOI]
  12. 12 Inflammatory markers in coronary heart disease [DOI]
  13. 13 Anemia in early rheumatoid arthritis is associated with interleukin 6-mediated bone marrow suppression, but has no effect on disease course or mortality.
  14. 14 Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease [DOI]
  15. 15 Soluble VE‐cadherin in rheumatoid arthritis patients correlates with disease activity: Evidence for tumor necrosis factor α–induced VE‐cadherin cleavage [DOI]
  16. 16 Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark [DOI]
  17. 17 An Overview of the Extraarticular Involvement in Rheumatoid Arthritis and its Management. [DOI]
  18. 18 Lipid abnormalities in patients with Rheumatoid Arthritis [DOI]
  19. 19 Dyslipidemia and changes in lipid profiles associated with rheumatoid arthritis and initiation of anti–tumor necrosis factor therapy [DOI]
  20. 20 Lipid Paradox in Rheumatoid Arthritis: Changes With Rheumatoid Arthritis Therapies [DOI]
  21. 21 Anti-Arthritic And Anti Inflammatory Activity Of Beta Caryophyllene Against Freund's Complete Adjuvant Induced Arthritis In Wistar Rats
  22. 22 Rheumatoid arthritis and herbal drugs: A review [DOI]
  23. 23 Protective Effects of a Polyherbal Formulation, Freemodex, Against Acute Models of Pain, Inflammation, Arthritis, and Immunosuppression [DOI]

Cited by 1

Perception and Acceptance of Herbal Medicines among Residents of Port Harcourt, Nigeria

K. Elechi-amadi, O. N. Briggs, F. E. Konne · 2021

Related research

Article metrics

Real usage data collected on this platform.

18

Page views

0

PDF downloads

3

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.