Alkaline Diuresis as Treatment for 2, 4-D Dimethylamine Herbicide Intoxication:  A Case Report

Nitesh Jindal; Tanu Raj Sirohi; Patamsetti Anil Kumar; Mohammad Shoeb; Gali Shabarish; Pediredla Sri Sowmya

doi:10.9734/ijmpcr/2022/v15i4317

Research Article Open access CC BY 4.0

Alkaline Diuresis as Treatment for 2, 4-D Dimethylamine Herbicide Intoxication: A Case Report

Nitesh Jindal, Tanu Raj Sirohi, Patamsetti Anil Kumar, Mohammad Shoeb, Gali Shabarish, Pediredla Sri Sowmya

International Journal of Medical and Pharmaceutical Case Reports · pp. 83–87 · Published 22 Nov 2022

10.9734/ijmpcr/2022/v15i4317

Abstract

The use of 2, 4-D dimethylamine is expanding as a result of the rise in glyphosate and paraquat resistance in weeds [1]. Instances of 2,4D dimethylamine intoxication have been on the rise. This herbicide exhibits a range of dose-dependent harmful mechanisms, including cell membrane destruction, disruption of acetyl coenzyme A metabolism, and oxidative phosphorylation uncoupling [2]. The neurological system, heart, lungs, liver, muscles, and endocrine system may all be affected by toxic effects [3]. Results in male cases are fatal [2,4]. The usefulness of alkaline diuresis as a life-saving treatment for 2,4-D dimethylamine poisoning with severe symptoms is discussed in this paper. 2, 4-D dimethylamine intoxication can be fatal if not treated promptly. There is no particular antidote and alkaline diuresis shows good result in the patient who present with severe intoxication of 2, 4-D dimethylamine.

Herbicide intoxication 2 4-D dimethylamine alkaline dieresis chlorphenoxy

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Nitesh Jindal, Tanu Raj Sirohi, Patamsetti Anil Kumar, Mohammad Shoeb, Gali Shabarish, Pediredla Sri Sowmya (2022). Alkaline Diuresis as Treatment for 2, 4-D Dimethylamine Herbicide Intoxication: A Case Report. International Journal of Medical and Pharmaceutical Case Reports , 83–87. https://doi.org/10.9734/ijmpcr/2022/v15i4317

Affiliations

Nitesh Jindal — Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Tanu Raj Sirohi — Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Patamsetti Anil Kumar — Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Mohammad Shoeb — Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Gali Shabarish — Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Pediredla Sri Sowmya — Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.

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