Alfavaca Aqueous Leaf Extract Protective and Ameliorative Effects on Lead Induced Hippocampus in Wistar Rats
Onoriode Andrew Udi, Trust Azubike Ijeomah, Lucky Omamuzo Ogagayere, Godswill Ogheneyebrorue Okoro
Asian Journal of Medicine and Health · pp. 8–15 · Published 16 Sep 2023
10.9734/ajmah/2023/v21i11914Abstract
There is a claim that using medicinal plants carelessly can be dangerous. The consequences of consuming numerous of these plants over time on the brain have remained a mystery. Alfavaca is one of such numerous herbs commonly used in Nigeria. This research was done to find out how Alfavaca leaf extract affected the hippocampus of wistar rats that had been exposed to lead acetate. There were five (5) groups of twenty-five (25) Wistar rats, each with five (5) rats. Group one (1) is a control group that merely received water and a typical rat meal, the experimental group consisted of Groups 2, 3, 4, and 5. These groups received aqueous Alfavaca leaf extract at a dose of 252.98 mg/kg/day for 35 days, 180 mg/kg of lead acetate for 21 days, 126.49 mg/kg bwt of Alfavaca leaf extract for 21 days, and 180 mg/kg of lead acetate for 21 days with a dose of 252.98 mg/kg bwt for 35 days, respectively. Rats were euthanized after the treatment period. For the collected brain tissue, the hippocampus, histological, biochemical, and stereological tests were also carried out. Malonaldehyde, Superoxide Dismutase, Glutathione, and Catalase levels in the hippocampus decreased significantly when compared to control (group I), indicating that the regeneration of injured glia cells (Gliosis) was fairly evenly distributed throughout groups. The current study's findings further imply that alfavaca extract is a potent positive attenuator of the histo-architectural framework of a degenerating brain tissue. Similar studies on other areas of the brain are highly recommended.
References (26)
- 1 Diabetes, oxidative stress, and antioxidants: A review [DOI]
- 2 Cancer Incidence in Egypt: Results of the National Population-Based Cancer Registry Program [DOI]
- 3 Oxidative stress and glycemic regulation [DOI]
- 4 Lead neurotoxicity: From exposure to molecular effects [DOI]
- 5 Drug-Loaded Carbon Nanohorns: Adsorption and Release of Dexamethasone in Vitro [DOI]
- 6 Flavonoids and phenolic acids: Role and biochemical activity in plants and human [DOI]
- 7 HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. mexicana [DOI]
- 8 Neuroprotective Efficacy of Eugenol and Isoeugenol in Acrylamide-Induced Neuropathy in rats: Behavioral and Biochemical evidence [DOI]
- 9 Antibacterial effects of extracts of Ocimum gratissimum and piper guineense on Escherichia coli and Staphylococcus aureus [DOI]
- 10 Eugenol protects neuronal cells from excitotoxic and oxidative injury in primary cortical cultures [DOI]
- 11 Eugenol [2-Methoxy-4-(2-propenyl)phenol] Prevents 6-Hydroxydopamine-Induced Dopamine Depression and Lipid Peroxidation Inductivity in Mouse Striatum [DOI]
- 12 Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils [DOI]
- 13 Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats [DOI]
- 14 In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain [DOI]
- 15 Development of catechin–phospholipid complex to enhance the bioavailability and modulatory potential against cadmium-induced oxidative stress in rats liver [DOI]
- 16 The role of GSH peroxidase in protecting the membrane of rat liver mitochondria [DOI]
- 17 Changes in Liver Histomorphology, Hematological Parameters and Lipid Profile of Cadmium-Exposed Rats Treated with Combined Leaf Extract of Vernonia amygdalina and Occimum gratissimum [DOI]
- 18 Lead II Acetate Induced Physio-Morphological Changes in Prefrontal Cortex of Ocimum gratissimum Fed Wistar Rats
- 19 Nutritional Knowledge and Body Mass Index among Students at Novena University, Ogume, Nigeria [DOI]
- 20 Mature Wistar Rats' Spleen and Liver Histomorphological Changes Related to the Duration of Atrazine Exposure [DOI]
- 21 Investigating the effect of Mimosa Pudica on dichlorvos induced hippocampal neurodegeneration in mice [DOI]
- 22 Studies on Cytomegalovirus Infection among HIV Positive Patients Attending Infectious Diseases Hospital, Kano State, Nigeria [DOI]
- 23 An analysis of the effects of Phoenix dactilifera crude extract on the GI Tract of Adult Albino Rats [DOI]
- 24 Anthropometric Indicators in Diet and Physical Activity [DOI]
- 25 Reversibility, Body Weight and Histo-architectural Alterations in the Anterior Pituitary Gland of Aqueous Azadirachta indica Extract Fed Wistar Rats [DOI]
- 26 An analysis of the effects of Phoenix dactilifera crude extract on the GI Tract of Adult Albino Rats [DOI]
Cited by 2
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