Evaluation of Serum IL-10, TNF-α and Albumin Levels among Male Type 2 Diabetes Mellitus Patients in a  Tertiary Hospital in Nigeria

Ehiaghe, F.A.; Ahmed, V.U.; EHIAGHE, J.I.; Ogalagu, R.O.; Obu, S.I.; Ize-Iyamu, J. A; Osakue, O.N.; Ogbodo, E.C.

doi:10.9734/ajmpcp/2025/v8i2303

Research Article Open access CC BY 4.0

Evaluation of Serum IL-10, TNF-α and Albumin Levels among Male Type 2 Diabetes Mellitus Patients in a Tertiary Hospital in Nigeria

Ehiaghe, F.A., Ahmed, V.U., EHIAGHE, J.I., Ogalagu, R.O., Obu, S.I., Ize-Iyamu, J. A, Osakue, O.N., Ogbodo, E.C.

Asian Journal of Medical Principles and Clinical Practice · pp. 437–445 · Published 20 Jun 2025

10.9734/ajmpcp/2025/v8i2303

Abstract

Type 2 diabetes (T2DM) is associated with a chronic inflammatory state and a disturbance in cytokine balance. This study aimed to evaluate the levels of TNF-α, IL-10, and albumin in the serum of males with type 2 diabetes compared to healthy individuals. A case-control study was conducted involving 60 participants (30 patients and 30 healthy individuals), and the samples were analyzed using ELISA techniques and the BCG method. The results showed a significant increase in TNF-α (53.97 ± 10.22 Vs 15.11 ± 2.82) and IL-10 (17.07 ± 1.42 Vs 4.12 ± 0.88) levels among the patients (P = <0.001), with no significant difference in albumin levels (p>0.05). The results indicate the presence of a simultaneous inflammatory and anti-inflammatory response, which underscores the importance of these cytokines as biomarkers in diabetes monitoring.

Diabetes mellitus inflammation biomarkers TNF-α IL-10 serum albumin male T2DM patients

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Ehiaghe, F.A., Ahmed, V.U., EHIAGHE, J.I., Ogalagu, R.O., Obu, S.I., Ize-Iyamu, J. A, Osakue, O.N., Ogbodo, E.C. (2025). Evaluation of Serum IL-10, TNF-α and Albumin Levels among Male Type 2 Diabetes Mellitus Patients in a Tertiary Hospital in Nigeria. Asian Journal of Medical Principles and Clinical Practice , 437–445. https://doi.org/10.9734/ajmpcp/2025/v8i2303

Affiliations

Ehiaghe, F.A. — Department of Immunology and Immunochemistry, Nnamdi Azikiwe University, Anambra State, Nigeria.
Ahmed, V.U. — Department of Clinical Chemistry, Nnamdi Azikiwe University, Anambra State, Nigeria.
EHIAGHE, J.I. — Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Benson Idahosa University, Benin City, Nigeria.
Ogalagu, R.O. — Department of Biochemistry, Faculty of Natural and Applied Sciences, Tansian University, Umunya, Nigeria.
Obu, S.I. — Centre for Communicable Disease Control and Research, Federal Medical Center, Asaba, Delta State, Nigeria.
Ize-Iyamu, J. A — Edo State Health Management Board, Benin City, Edo State, Nigeria.
Osakue, O.N. — Department of Clinical Chemistry, Nnamdi Azikiwe University, Anambra State, Nigeria.
Ogbodo, E.C. — Department of Clinical Chemistry, Nnamdi Azikiwe University, Anambra State, Nigeria.

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