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Research Article Open access CC BY 4.0

Actinobacteria: Versatile Microorganisms with Medical and Pharmaceutical Application

Rosilma de O. Araujo-Melo, Igor F. A. C. Souza, Maria C. V. Vicalvi-Costa, Janete M. de Araújo, Kêsia X. R. F. de Sena, Luana C. B. B. Coelho

Biotechnology Journal International · pp. 1–13 · Published 31 Aug 2016

10.9734/BBJ/2016/28728

Abstract

The Actinobacteria receive much attention, since they produce a variety of metabolites, including antibiotics and enzyme inhibitors. These bacteria are distributed in various habitats, including soil, ocean, extreme environments, lichen, plants, and animals. The classification of Actinobacteria based upon the morphological observation, physiological and biochemical characteristics were not adequate to differentiate the genera of this phylum. Following, another identification was available based in the distribution of specific constituents from the cellular wall, such as diaminopimelic acid and carbohydrates. With the advent of molecular biology, the identification of genera and species was more reliable. The screening of microbial natural products has become an important route to discover new bioactive compounds in order to develop new therapeutic agents. Actinobacteria remains one of the leading producers of biopharmaceuticals; endophytic Actinobacteria also yield secondary metabolites with wide range of biological activity. This review focus on gathering relevant information on identification, classification, chemical diversity of Actinobacteria, as well as reveals some biotechnological applications of these bacteria.  

Actinobacteria microorganisms biotechnology potential

References (47)

  1. 1 Bioactive Microbial Metabolites [DOI]
  2. 2 Taxonomy, Physiology, and Natural Products of Actinobacteria [DOI]
  3. 3 Proposal for a New Hierarchic Classification System, Actinobacteria classis nov. [DOI]
  4. 4 Chemical composition as a criterion in the classification of aerobic actinomycetes [DOI]
  5. 5 Numerical Classification of Streptomyces and Related Genera [DOI]
  6. 6 Antibiotics produced by Streptomyces [DOI]
  7. 7 The Nomenclature and Classification of the Actinomycetes [DOI]
  8. 8 Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans a aThe GenBank accession number for the sequence determined in this work is AY127079. [DOI]
  9. 9 The taxonomy of Streptomyces and related genera. [DOI]
  10. 10 A guide to successful bioprospecting: informed by actinobacterial systematics [DOI]
  11. 11 Diversity of actinomycetes isolated from Challenger Deep sediment (10,898 m) from the Mariana Trench [DOI]
  12. 12 Biocontrol of Rhizoctonia solani damping-off and promotion of tomato plant growth by endophytic actinomycetes isolated from native plants of Algerian Sahara [DOI]
  13. 13 Rapid identification of filamentous actinomycetes to the genus level using genus-specific 16S rRNA gene restriction fragment patterns [DOI]
  14. 14 Endophytic microorganisms—promising applications in bioremediation of greenhouse gases [DOI]
  15. 15 Modern Industrial Microbiology and Biotechnology [DOI]
  16. 16 Diversity of Cultivated and Uncultivated Actinobacterial Endophytes in the Stems and Roots of Rice [DOI]
  17. 17 Isolation of rhizospheric and roots endophytic actinomycetes from Leguminosae plant and their activities to inhibit soybean pathogen, Xanthomonas campestris pv. glycine [DOI]
  18. 18 Diversity of endophytic actinomycetes in mandarin grown in northern Thailand, their phytohormone production potential and plant growth promoting activity [DOI]
  19. 19 Quantitative isolation of biocontrol agents Trichoderma spp., Gliocladium spp. and actinomycetes from soil with culture media [DOI]
  20. 20 Signature proteins that are distinctive characteristics of Actinobacteria and their subgroups [DOI]
  21. 21 Detection of antitumor and antimicrobial activities in marine organism associated actinomycetes isolated from the Taiwan Strait, China [DOI]
  22. 22 Alnumycin a New Naphthoquinone Antibiotic Produced by an Endophytic Streptomyces sp. [DOI]
  23. 23 Bacterial diversity and bioprospecting for cold-active enzymes from culturable bacteria associated with sediment from a melt water stream of Midtre Lo v ´ enbreen glacier, an Arctic glacier [DOI]
  24. 24 Genetic diversity of endophytic bacteria which could be find in the apoplastic sap of the medullary parenchym of the stem of healthy sugarcane plants [DOI]
  25. 25 Response of micropropagated sugarcane varieties to inoculation with endophytic diazotrophic bacteria [DOI]
  26. 26 Endophytic Actinobacteria from the Brazilian Medicinal Plant Lychnophora ericoides Mart . and the Biological Potential of Their Secondary Metabolites [DOI]
  27. 27 Continuing hunt for endophytic actinomycetes as a source of novel biologically active metabolites [DOI]
  28. 28 Biodiversity of Actinomycetes Associated with Caribbean Sponges and Their Potential for Natural Product Discovery [DOI]
  29. 29 Nocardiopsins: New FKBP12‐Binding Macrolide Polyketides from an Australian Marine‐Derived Actinomycete, Nocardiopsis sp. [DOI]
  30. 30 Antimicrobial properties of endophytic actinomycetes isolated from Combretum latifolium Blume, a medicinal shrub from Western Ghats of India [DOI]
  31. 31 Biotechnological potential of endophytic actinomycetes associated with Asteraceae plants: isolation, biodiversity and bioactivities [DOI]
  32. 32 Isolation and screening for plant growth-promoting (PGP) actinobacteria from Araucaria angustifolia rhizosphere soil [DOI]
  33. 33 Phylogenetic diversity of culturable bacteria from Antarctic sandy intertidal sediments [DOI]
  34. 34 Isolation and bioactivity of endophytic filamentous actinobacteria from tropical medicinal plants [DOI]
  35. 35 Antimicrobial potential of actinobacteria isolated from the rhizosphere of the Caatinga biome plant Caesalpinia pyramidalis Tul. [DOI]
  36. 36 Rapid method for the detection and identification of mycolic acids in aerobic actinomycetes and related bacteria [DOI]
  37. 37 Cytoskeletal Proteins ofActinobacteria [DOI]
  38. 38 Isolation, structure elucidation and biological activity of angucycline antibiotics from an epiphytic yew streptomycete [DOI]
  39. 39 Haloalkaliphilic actinomycetes in soils of Mongolian desert steppes [DOI]
  40. 40 Streptomyces genes: from Waksman to Sanger [DOI]
  41. 41 Antibiotic produced by streptomycetes associated with rhizosphere of purple nut sedge (Cyperus rotundus L.) in Surakarta, Indonesia [DOI]
  42. 42 Identification of a novel fumarase C from Streptomyces lividans TK54 as a good candidate for l-malate production [DOI]
  43. 43 Screening of membrane active antimicrobial metabolites produced by soil actinomycetes using membrane models [DOI]
  44. 44 Taxonomy, fermentation, biological activities, isolation and characterization of metabolites obtained from a new strain of Streptomyces noursei (KC46)
  45. 45 Bergey's Manual of Systematic Bacteriology [DOI]
  46. 46 Bergey's Manual of Determinative Bacteriology [DOI]
  47. 47 [Comparative genetics and evolutionary morphology of symbiosis formed by plants with nitrogen-fixing microbes and endomycorrhizal fungi].

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