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Research Article Open access CC BY 4.0

AA Amyloidosis Secondary to Horton's Disease Complicated by Pulmonary Fibrosis: A Very Challenging Diagnosis and Therapy

M. Njie, P. M. Mulendele, O. Mokni, M. Sidi Boutar, M. HABOUB, S. AROUS, M. Ghali Benouna, A. DRIGHIL, L. Azzouzi, R. HABBAL

Cardiology and Angiology: An International Journal · pp. 144–153 · Published 3 Jul 2023

10.9734/ca/2023/v12i4353

Abstract

AA amyloidosis is a classic and serious complication of many chronic inflammatory processes, whether of infectious, autoimmune, or neoplastic origin. It is frequently complicated by kidney damage, often in the form of a nephrotic syndrome. Giant cell arteritis is a common inflammatory arteritis in the elderly; however, it rarely causes AA amyloidosis. We report a rare case of Horton disease causing AA amyloidosis in an elderly patient with history of myopericarditis and repeated episodes of congestive heart failure. Patient was treated initially with dual therapy based on corticosteroids and anti TNF therapy (Tocilizumab) associated with heart failure therapy recommended by the European society of cardiology (ESC 2021 guidelines on Heart Failure). The initial outcome was favorable but later complicated by the involvement of the lungs; pulmonary fibrosis, responsible for repeated episodes of pleural effusion non controlled in spite of high dose of loop diuretics and repeated pleural punction. Patient died shortly after her second hospitalization due to respiratory insufficiency.

Horton disease AA amyloidosis pulmonary fibrosis Cardiac MRI corticosteroids and Tocilizumab

References (8)

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