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Research Article Open access CC BY 4.0

Anhidrotic Ectodermal Dysplasia: Report of Two Cases

Narjess Er-rachdy, Ouissal Essadeq, Laila Benzekri, Nadia Ismaili

Asian Journal of Pediatric Research · pp. 45–49 · Published 31 Jul 2025

10.9734/ajpr/2025/v15i7467

Abstract

Background: Anhidrotic ectodermal dysplasia (AED), also referred to as hypohidrotic ectodermal dysplasia, is a rare genetic condition characterized by a triad of hypotrichosis, hypodontia, and hypohidrosis. Case Report: This article reports two illustrative cases: an adolescent and a child, both presenting with classic AED manifestations. Discussion: We describe the clinical and histological features, provide insights into the diagnostic process, and discuss recent advances in the understanding and management of AED. Conclusion: AED is a rare genetic disorder that requires early diagnosis, regular follow-up, and genetic counseling. New therapies offer promising outcomes.

Anhidrotic ectodermal dysplasia EDA mutation hypohidrosis dental anomalies prenatal therapy recombinant EDA-A1 genetic counseling

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