Effect of 67Zn-Nanoparticles on Leukemic Cells and Normal Lymphocytes
Marina A. Orlova, Elena Yu. Osipova, Sergey A. Roumiantsev
Journal of Advances in Medicine and Medical Research · pp. 21–30 · Published 8 Dec 2011
10.9734/BJMMR/2012/783Abstract
Porphyrin-fulleren-based nanoparticles (NP), containing magnetic isotopes 25Mg, 67Zn and zinc of natural isotope composition (Zntotal-NP), have been tested on leukemic cells of patients with T-ALL, B-ALL, AML and lymphocytes of healthy donors. Reliable differences in action of magnetic and non-magnetic zinc isotopes for some types of cells were obtained. Magnetic magnesium isotopes and pure nanoparticles of porphyrinfulleren did not demonstrate any effects. 67Zn-NP induced high cytotoxicity in cells of acute B-lymphoblastic leukemia with LD50 almost three times lower, than those for healthy donors, and 4 times lower in comparison with Zntotal-NP. Also evaluation of apoptosis process in granulocytes of healthy donors in the case of the preparates were performed by method of flow cytometry.
Cited by 31
M.A. Orlova, A.L. Nikolaev, T.P. Trofimova · Bulletin of Russian State Medical University · 2018
M. A. Orlova, S. A. Roumiantsev, A. P. Orlov · Russian Chemical Bulletin · 2014
Tatiana P. Trofimova, Fedor S. Chikunov, Alexey N. Proshin · Mendeleev Communications · 2023
Alexander A. Bukhvostov, Anton S. Dvornikov, Kirill V. Ermakov · Acta Medica (Hradec Kralove, Czech Republic) · 2017
М. А. Орлова, А. Л. Николаев, Т. П. Трофимова · Вестник Российского Государственного медицинского университета · 2018
Tatiana P. Trofimova, Victor A. Tafeenko, Alexey S. Borodkov · Mendeleev Communications · 2021
T. P. Trofimova, M. A. Orlova, A. V. Severin · Russian Chemical Bulletin · 2018
VV Fursov, DI Zinchenko, DD Namestnikova · Bulletin of Russian State Medical University · 2022
Vasily Spiridonov, Marina Orlova, Igor Ivanov · Colloids and Surfaces A: Physicochemical and Engineering Aspects · 2020
Marina A. Orlova, Tatiana P. Trofimova, Ramiz A. Aliev · Journal of Radioanalytical and Nuclear Chemistry · 2016
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