A Study on the Phytochemistry and Thrombolytic Effect of Thaumatophyllum bipinnatifidum Methanolic and Acetonic Extracts

Abstract

Introduction: Medicinal plants have long served as a valuable source of therapeutic agents due to their diverse phytochemical constituents and associated pharmacological effects. Among these, thrombolytic agents derived from natural sources have gained scientific interest as potential alternatives to synthetic drugs. Thaumatophyllum bipinnatifidum, a plant traditionally used for its medicinal value, contains various bioactive compounds that may contribute to cardiovascular health through thrombolytic activity. Aims: The objective of this study was to investigate the presence of major phytochemicals and evaluate the thrombolytic potential of methanolic and acetonic extracts of Thaumatophyllum bipinnatifidum leaves, stems, and roots. Methodology: Phytochemical screening was performed on the methanolic and acetonic extracts of Thaumatophyllum bipinnatifidum to identify major secondary metabolites. The thrombolytic activity of these extracts was assessed using an in vitro clot lysis method, with streptokinase serving as the positive control and distilled water as the negative control. Conclusion: Phytochemical analysis revealed the presence of alkaloids, saponins, and tannins in the extracts. Both methanolic and acetonic extracts of Thaumatophyllum bipinnatifidum demonstrated significant thrombolytic activity, suggesting their potential use in developing natural thrombolytic agents. Further research is warranted to isolate the active compounds and evaluate their mechanisms of action.