A Review on Chemical Permeation Enhancers used in the Formulation of Transdermal Drug Delivery System
Journal of Pharmaceutical Research International · pp. 429–437 · Published 16 Dec 2021
10.9734/jpri/2021/v33i59A34288Abstract
Skin penetration enhancement technology is a rapidly evolving area that will greatly increase the quantity of transdermal drug delivery medications. Penetration enhancers are used to facilitate the movement of drugs through the skin barrier. Numerous methods exist for extending partition enhancement. The enhancers' contact with the polar head of the lipid groups is the potential means for increasing the penetration. Penetration enhancers improve the amount of free water molecules between the bilayer, leading to an improvement of the polar drug diffusion cross section. This article focuses on the different compounds assessed for improving penetration activity like sulphoxides, azones, pyrrolidones, alcohols and alkanols, glycols, surfactants and terpenes.
Cited by 2
Yanan Liu, Man Li, Daoxuan Xie · International Journal of Pharmaceutics: X · 2025
Yanan Liu, Guixue Chen, Maojian Li · International Journal of Pharmaceutics: X · 2025
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