A Review on Anthracycline Induced Cardiotoxicity- A Mechanism-based Approach
Sachin M. Hiradeve, Vaibhav P. Uplanchiwar, Namrata Mane, Gayatri Katole, Sanjana N. Gaikwad, Mayuri N. Deshmukh, Swati G. Gaikwad, Priya V. Nikam, Abhinav Bais, Vijendra Fulzele, Trupti S. Bobade, Mohd. Hashim Mansoori
Journal of Pharmaceutical Research International · pp. 19–25 · Published 3 Feb 2022
10.9734/jpri/2022/v34i7B35468Abstract
Doxorubicin has become one of the most effective chemotherapeutic agents, but its use was complicated by the development of heart failure. Proposed mechanisms for its antitumor effects included intercalation into DNA that caused the prevention of micro molecule synthesis, DNA cross-linkage and binding, DNA damage due to topoisomerase 2b suppression, reactive oxygen species production, and induction of apoptosis. Several drugs such as ACE inhibitors or the angiotensin receptor blockers, beta-blockers and the CHF therapy are used for the treatment processes. The present brief review of the literature, focuses on literature based on the mechanism of anthracycline-induced cardiotoxicity.
Cited by 7
Sanjana Arsha, Ashish Tripathi, John Kangarlu · Cardiology in Review · 2025
András Nagy, Denise Börzsei, Alexandra Hoffmann · Cardiovascular Drugs and Therapy · 2024
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