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Research Article Open access CC BY 3.0

A Review of Low Angle Fibre Diffraction in the Diagnosis of Disease

Veronica J. James

Journal of Advances in Medicine and Medical Research · pp. 383–397 · Published 19 Feb 2013

10.9734/BJMMR/2013/2432

Abstract

More than ever, unlocking the secrets of cancer in the 21st century is a collaborative exercise between medical science and a greater use of all available forms of technology. Peeling away the layers that surround cancer diagnoses reveals a deeper understanding about the nature of cancer conditions. The use of technology thus may aid the process of early diagnosis. The information gained by each successful step in turn adds to our existing understanding and helps to direct the course of improved treatment protocols. Treatment protocols resulting from our greater understanding of the cancers bring us one step closer to our ultimate goal of better interventions for all patients suffering from a range of cancer conditions. One such method of investigation has been the use of low angle fibre diffraction techniques in the analysis of body tissues, including skin, hair and nails. The results obtained produce characteristic diffraction patterns which are distinctive and reproducible for a number of cancers including breast cancer, prostate cancer and melanoma. These patterns may be used as a means of early detection of some of the most commonly occurring cancers, or, alternatively, as an indicator that cancers which have previously been diagnosed for particular patients have been cured and no trace of the disease remains in the patient’s body.

Low angle fibre diffraction cancer

References (22)

  1. 1 The Iraf Data Reduction And Analysis System [DOI]
  2. 2 Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer’s disease [DOI]
  3. 3 An unusual collagen periodicity in skin [DOI]
  4. 4 Skin collagen has an unusual d-spacing [DOI]
  5. 5 Breast-cancer diagnosis using hair [DOI]
  6. 6 Diagnosis of breast cancer by X‐ray diffraction of hair [DOI]
  7. 7 The importance of good images in using hair to screen for breast cancer [DOI]
  8. 8 Early diagnosis of breast cancer by hair diffraction [DOI]
  9. 9 Is there a correlation between the structure of hair and breast cancer or BRCA1/2 mutations? [DOI]
  10. 10 Breast Cancer Screening Using Small-Angle X-ray Scattering Analysis of Human Hair [DOI]
  11. 11 Characterization of a Test for Invasive Breast Cancer Using X-ray Diffraction of Hair—Results of a Clinical Trial [DOI]
  12. 12 Synchrotron fibre diffraction identifies and locates foetal collagenous breast tissue associated with breast carcinoma [DOI]
  13. 13 The Molecular Architecture for the Intermediate Filaments of Hardα-Keratin Based on the Superlattice Data Obtained from a Study of Mammals Using Synchrotron Fibre Diffraction [DOI]
  14. 14 Synchrotron X-ray study at Trieste: No correlation between breast cancer and hair structure [DOI]
  15. 15 Changes in the Molecular Structure of Hair in Insulin-Dependent Diabetes [DOI]
  16. 16 Hair test results at the advanced polymers beamline (X27C) at the NSLS [DOI]
  17. 17 Fibre diffraction from a single hair can provide an early non-invasive test for colon cancer.
  18. 18 Attempts to replicate the claim of James' at NSLS beam line X12B [DOI]
  19. 19 Molecular structural changes in human fetal tissue during the early stages of embryogenesis [DOI]
  20. 20 Fibre diffraction of hair can provide a screening test for Alzheimer's disease: a human and animal model study.
  21. 21 Changes in the diffraction pattern of hair resulting from mechanical damage can occlude the changes that relate to breast cancer [DOI]
  22. 22 Extremely Early Diagnostic Test for Prostate Cancer [DOI]

Cited by 8

Using Physics to Diagnose Cancer

Veronica J. James · Biophysical Reviews and Letters · 2014

Fibre Diffraction Analysis of Skin Offers a Very Early and Extremely Accurate Diagnostic Test for Prostate Cancer

Veronica J. James, Judith M. O’Malley Ford · Journal of Cancer Research · 2014

Showing 3 of 8 known citations — external sources report more than can currently be individually listed.

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