A Retrospective Cross Sectional Study to Find out the Role of Biochemical Parameters in Assessing the Severity of SARS COVID-19

Abstract

Background and Objective: SARS Cov 2 virus are spreading havoc throughout the world and is responsible for the present pandemic. The clinical presentation of this pandemic has been varied from simple flu like symptoms to severe pneumonia. It is also found to affect multiple organ systems in our body.This study was conducted to find out the variations in the biochemical parameters among SARS Covid patients admitted in our hospital. Materials and Methods: This study was a retrospective cross sectional survey of medical records of 258 SARS Cov 2 patients admitted in Chettinad hospital and research institute from July 2020 to September 2020. Among them 183 were males,75 were females. The details of their liver profile, renal profile, cardiac profile, ferritin levels and LDH levels were retrieved and studied Results: In this study we found a significant difference in the levels of ferritin, LDH, serum albumin, troponin I, CK-MB and BNP levels between patients admitted in ICU and ward. The patients were divided into three groups based on their age as 20-50,50-80 and more than 80 years. We found significant difference in the levels of total protein, serum albumin, ALT, BUN, troponin I and CK –MB values. Regression analysis showed ferritin, LDH and serum albumin to be independent markers in predicting disease severity (p value <0.05). Conclusion: This study has shown that ferritin, LDH and serum albumin are promising biochemical markers in the diagnosis and prognosis of SARS Covid 19 infection.