A New Anionic Bovine Tendon as Scaffold for the Repair of Bone Defects: A Morphological, Histomorphometric and Immunohistochemical Study
Rogerio L. Buchaim, Marcelie P. de O. Rosso, Jesus C. Andreo, Daniela V. Buchaim, Roberta Okamoto, Antonio de C. Rodrigues, Andre L. Shinohara, Jose S. Roque, Domingos D. Roque, Geraldo M. Rosa Junior, Gilberto Goissis
Journal of Advances in Medicine and Medical Research · pp. 1–11 · Published 24 Aug 2015
10.9734/BJMMR/2015/19678Abstract
Aim: The process of bone repair is of evident importance in both the clinical and functional spheres. For this reason, the field of bioengineering has taken it as an object of study, seeking to perfect the implantation of materials that allow for adequate bone neoformation. This study investigated the process of bone repair after anionic bovine tendon grafting in rat tibias by conducting a morphological, histomorphometric and immunohistochemical study. Methodology: The experimental model consisted of 36 rats randomly divided into two groups: a control group (CG, n=18), in which a surgical cavity in the tibia was filled with blood clots; and an experimental group (EG, n=18), in which a surgical cavity in the tibia was filled with an anionic bovine tendon graft. In the experimental group, the major axis of the collagen fiber bundle was placed perpendicularly to the long axis of the tibia. Microscopic, morphometric and immunohistochemical evaluations were conducted at 7, 15, and 30 days postoperative. Results: The analyzes showed an increase in bone neoformation in the experimental group during the assessed periods. There was a significant difference between day 7 and day 30 and evident vascular proliferation was detected by the immunohistochemical analysis. Conclusion: It can be concluded that the anionic bovine tendon collagen proved to be an adequate and biocompatible material for bone regeneration, with osteogenic capabilities that allow it to be used as a scaffold for bone repair.
Cited by 4
Marcelie Priscila de Oliveira Rosso, Aline Tiemi Oyadomari, Karina Torres Pomini · Biomolecules · 2020
Fernando Bento Cunha, Karina Torres Pomini, Ana Maria de Guzzi Plepis · Molecules · 2021
Jéssica Barbosa de Oliveira Gonçalves, Daniela Vieira Buchaim, Cleuber Rodrigo de Souza Bueno · Journal of Photochemistry and Photobiology B: Biology · 2016
Marcelie Priscila de Oliveira Rosso, Daniela Vieira Buchaim, Karina Torres Pomini · Materials · 2019
Related research
- Immunohistochemical Expression of Epstein-Bar Virus in Biopsies Bearing Oral Squamous Cell Carcinoma — shares topic coverage
- Mantle Cell Lymphoma of Gastrointestinal Tract as a Lead Point for Intussusception: A Case Report — shares topic coverage
- Histochemical and Morphological Evaluation of the Conventional Versus Two Rapid Microwave Tissue Processing Techniques — shares topic coverage
- Neoplasias in Fish: Review of the Last 20 Years. A Look from the Pathology — shares topic coverage
- Ameliorative Properties of the Chloroform Stem Bark Extract of Abrus precatorius against Gentamicin-induced Renal Damage in Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
4
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.