A Combined Treatment Effect of Cilostazol and Pentoxifylline in the Treatment of Peripheral Vascular Disease
Jalpa Suthar, Birju Shah, Ritu Ranjan
Asian Journal of Medicine and Health · pp. 74–80 · Published 3 Sep 2022
10.9734/ajmah/2022/v20i1130528Abstract
Background: In past comparative studies in peripheral vascular disease (PVD) showed Cilostazol was efficient in relieving intermittent claudication as compared to Pentoxifylline. Objectives: The present study was planned to assess the effect the combination of cilostazol (50 mg BD) and pentoxifylline (400 mg TDS) therapy in patients with PVD. Additionally, the adverse effects and economic burden of the combination was taken in to account. Methodology: An Observational antegrade study was done among 100 patients. A Patient with PVD visited to OPD of the vascular department was enrolled in the study. Data was collected as per the Case Record Form. Results: The mean age was found to be 58.4 ± 11.3 years of total 100 patients. An improvement in a Doppler testing (follow-up at the time interval after 1 month, 3 months and 6 months) and increased in peak systolic velocity in distal vessels as well as collaterals were observed in all patients. The PVD was prevalent in 50 to 60 years of age groups and hypertension and smoking were the most common risk factors present in PVD patients. There was more than 70% increase in walking distance after 24 weeks of treatment. Headache 24 (36.4%) and Dizziness 9 (13.6%) were observed as common side effect of therapy. The total cost of the combination therapy was affordable with improved quality of life. Conclusion: The combination treatment showed symptomatic improvement in peripheral vascular disease in the study. The peak systolic velocity gradually increased in the distal vessel and the combination was found to be cost-effective.
References (15)
- 1 A comparison of cilostazol and pentoxifylline for treating intermittent claudication [DOI]
- 2 Overview of Classification Systems in Peripheral Artery Disease [DOI]
- 3 Drug Therapy for Improving Walking Distance in Intermittent Claudication: A Systematic Review and Meta-analysis of Robust Randomised Controlled Studies [DOI]
- 4 Cilostazol: a Review of Basic Mechanisms and Clinical Uses [DOI]
- 5 Effect of Cilostazol in Patients with Intermittent Claudication: A Randomized, Double-Blind, Placebo-Controlled Study [DOI]
- 6 Recent advances in magnetic resonance imaging for peripheral artery disease [DOI]
- 7 Safety of cilostazol in peripheral artery disease: a cohort from a primary healthcare electronic database [DOI]
- 8 Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review [DOI]
- 9 Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis [DOI]
- 10 Doppler Ultrasound as a Unique Diagnosis Test in Peripheral Arterial Disease [DOI]
- 11 Accuracy of Doppler Ultrasonography in Assessment of Lower Extremity Peripheral Arterial Diseases [DOI]
- 12 Drug Therapy for Improving Walking Distance in Intermittent Claudication: A Systematic Review and Meta-analysis of Robust Randomised Controlled Studies [DOI]
- 13 Peripheral arterial disease [DOI]
- 14 A comparative study of cilostazol and pentoxifylline in intermittent claudication in peripheral arterial disease [DOI]
- 15 Association between Rutherford Classification and CHA2DS2-VASc, CHADS2 and ASCVD Scores in Peripheral Artery Disease Patients [DOI]
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