Yam and Moringa oliefera Seed Blend in Lipid Profile Disorders, Kidney and Liver Toxicities, in Alloxan Induced Diabetic Rats

Abstract

Background and Aim: Diabetes mellitus is a chronic and very prevalent metabolic disease condition characterized by the abnormally high blood sugar level that eventually gives rise to diabetic complications affecting human and animals. Insulin deficiency increases free fatty acid influx and triglyceride levels into the blood, with reciprocal decrease in high-density lipoprotein (HDL) level. Numerous plants have in the past been screened for antidiabetic effects. Plants with medicinal property had served as anti-diabetic In this study; three yam varieties namely Dioscorea alata, Dioscorea cayennessis and Dioscorea rotundata sourced from Wuruku Market, Benue State Nigeria were evaluated for possible anti-diabetic effects. Methods: The collected Moringa seeds were processed into flour. Moringa oleifera seed 45 male albino rats assigned into 9 groups of 5 rats each were used for the study. Eight groups were induced with alloxan monohydrate and were confirmed to be diabetic after two days before treatment with Dioscorea alata control (100%) at 90% + 10% commercial feed, DA90%MRGA10% at (90%) +10% commercial feed, Dioscorea rotundata control (100%) at 90+10% commercial feed, DR90%MRGA10%, at (90%) +10% commercial feed, Dioscorea cayennesis control (100%) at 90% + 10% commercial. DC90%MRGA10% at (90%) +10%commercial feed, Moringa seed meal (100%) at 90% + 10% commercial feed, and 100% commercial feed. Both GRP8 (non-diabetic group) and GRP 9 (diabetic untreated group), were feed with rat Chow only. At the end of 28dys, the rats were sacrificed and the kidney, liver toxicities and lipid profile disorders were all investigated. Results: Result generated showed that diabetes caused liver, kidney toxicity and lipid disorder as evidence in the diabetic untreated groups (GRP9).Groups that received yam/moringa seed meal had significantly decreased (P<0.05) triglycerides (TG), cholesterol (Chol), high density lipoprotein-cholesterol (HDL-C) and VLDL and Serum Liver level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Total protein, Albumin, Creatinine and Urea when compared with diabetic untreated group. Conclusion: A combination of Moringa seed flour and some yam species may be of value in the management of diabetes mellitus and its associated complications.