Radioiodination and Biological Evaluation of Epinephrine as a Possible Adrenergic Receptors Imaging Agent
A. M. Amin, I. T. Ibrahim, S. M. Abd-elhaliem
International Journal of Biochemistry Research & Review · pp. 1–8 · Published 9 Sep 2014
10.9734/IJBCRR/2015/10616Abstract
Radioiodination and Biological Evaluation of Epinephrine as a Possible Adrenergic Receptors Imaging Agent An adopted method for the preparation of high radiochemical purity [125I] iodoepinephrine was developed in order to characterize the binding properties of adrenergic receptors. Direct radioiodination of epinephrine was carried out using chloramine-T as oxidizing agent. The reaction proceeds well within 15 min at ambient room temperature up to 25+1ºC and afforded a radiochemical yield up to 94%. Different chromatographic techniques (electrophoresis and paper chromatography) were used to evaluate the radiochemical yield and purity of the labeled product. Biodistribution studies were carried out in normal Albino Swiss mice and the results showed rapid and high cardiac uptake of 125I-epinephrine. The result indicates the possibility of using radioiodinated epinephrine as myocardial imaging agent.
Cited by 1
E. H. Borai, M. H. Sanad, A. S. M. Fouzy · Radiochemistry · 2016
Related research
- Analysis of Radiation Dose Distribution and Organs at Risk in Breast Cancer Using Intensity Modulated Radiation Therapy Technique on A Linear Accelerator at RSUP Prof. Dr. I.G.N.G. Ngoerah — shares topic coverage
- Cardiac and Hepatic miRNAs Altered Expression in Rat Embryo after Bisphenol-A (BPA) Exposure and Their Histopathological Impact (In vivo Study) — shares topic coverage
- Oxytocin Hormone Administration Attenuates Cardiac Oxidative Injury and Inflammation in Hypercholesterolemic Rats — shares topic coverage
- Dose-dependent Effect of Avocado Peel Hydroethanolic Extract on Antioxidant Status of Heart and Kidney Tissue Homogenates in Wistar Rats — shares topic coverage
- Death Due to Low Voltage Electric Shock Induced Myocarditis — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.