An Evaluation of Anti-hyperlipidemic Activity of Ethanolic Extract of (Asparagus racemosus) Leaves on High Fat Diet Induced Hyper Lipidemic Rat Model

Abstract

Traditional medicine, according to the World Health Organization, encompasses the knowledge, skills, and practices derived from the theories, beliefs, and experiences of various cultures. It is used to maintain health and prevent, diagnose, improve, or treat physical and mental illnesses. The liver is an essential organ for human metabolism, however; eating excessive high-fat foods can cause hyperlipidemia, a frequent chronic condition. Current hyperlipidemia medications, such as statins, have serious side effects and are inexpensive. Researchers are looking for alternative, natural medicines, and one such possibility is the plant Asparagus racemosus, which has long been utilized in Asia continent for its medicinal benefits. This research examined the effects of Asparagus racemosus extract on lipid profiles in rats that had developed hyperlipidemia due to a high-fat diet. Neither the SGPT nor SGOT values yielded statistically significant findings (p<0.05) in the liver function test. The renal function test revealed that there was no significant statistical variation in the levels of urea. Nevertheless, the examination of the creatinine levels revealed statistically significant outcomes (p< 0.05) in groups 5 and 6, where the dosage of high fat and extract administered was 600 and 900 mg/kg, respectively. Groups 5 and 6 showed statistically significant results (p<0.05) for high-density lipoprotein (HDL); however, only group 6 produced statistically significant outcomes (p<0.05) for low-density lipoprotein (LDL). Groups 5 and 6 were given dosages of 600 and 900 mg/kg, respectively. There was a significant statistical difference (p<0.05) in the triglyceride levels between groups 5 and 6. The data referring to total cholesterol levels did not demonstrate any statistical significance. Additionally, this study included an investigation of the effects of an ethanolic extract of Asparagus racemosus on lipid profiles in hyperlipidemic rats.